Four-stranded DNA helices: conformational analysis of regular poly(dT).poly(dA).poly(dA).poly(dT) helices with various types of base binding

Journal of Biomolecular Structure & Dynamics
A A ChernyĭV A Florentiev

Abstract

The paper presents results obtained in conformational analysis of homopolymeric four-stranded poly(dT).poly(dA).poly(dA).poly(dT) DNA helices in which the pairs of strands with identical bases are parallel and have a two-fold symmetry axis. All possible models of base binding to yield a symmetric complex have been considered. The dihedral angles of sugar-phosphate backbones and helix parameters, which are consistent with the minima of conformational energy for four-stranded DNAs, have been determined using the results of optimization of conformational energy calculated at atom-atom approximation. Potential energy is shown to depend on the structure of base complexes and on the mutual orientation of unlike strands. Possible biological functions of four-stranded helices are discussed.

References

Feb 1, 1990·Journal of Biomolecular Structure & Dynamics·I A Il'ychovaV A Florentiev
Feb 1, 1989·Journal of Biomolecular Structure & Dynamics·R E Dickerson
Feb 13, 1989·FEBS Letters·A K ShchyolkinaV L Florentiev
Sep 1, 1986·Biopolymers·N Pattabiraman
Jan 28, 1971·Journal of Molecular Biology·S McGavin
Mar 11, 1982·Nucleic Acids Research·V B ZhurkinV I Ivanov

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Citations

Feb 12, 2004·Journal of the American Chemical Society·Zhiyong ShenNadrian C Seeman
Jun 1, 1994·Journal of Biomolecular Structure & Dynamics·A K ShchyolkinaN A Tchurikov

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