PMID: 6972148Mar 1, 1981Paper

Four-year-old children with alpha 1-antitrypsin deficiency. Clinical follow-up and parental attitudes towards neonatal screening

Acta paediatrica Scandinavica
T Sveger, T Thelin

Abstract

Two hundred thousand infants born in Sweden between November 1972 and September 1974 were screened at birth for alpha 1-antitrypsin (alpha 1 AT) deficiency. At age 4 years 172 of 183 children with alpha 1 AT deficiency were examined and compared with 80 randomly selected control children. The children with alpha 1 AT deficiency had the following Pi types: 118 PiZ, 50 PiSZ, 2 PiZ-, 1 PiS-, 1 PiFZ. Two PiZ children have severe liver cirrhosis and 1 PiZ boy had died of aplastic anemia. Abnormal levels of serum alanine aminotransferase (S-ALAT) were found in one PiSZ and 47 PiZ children. Upper and lower respiratory infections, otitis, eczema, urinary infections or complications of child diseases did not occur more often in children with alpha 1 AT deficiency than in controls. More parents of alpha 1 AT deficient children had stopped smoking and their fathers smoked significantly less. Forty parents of children with alpha AT deficiency PiZ answered a questionnaire concerning their reaction to, knowledge about and attitudes towards neonatal screening for alpha 1 AT deficiency. Many parents reported having reacted with lack of understanding, shock or depression upon learning that the child had alpha 1 AT deficiency. About 4 years late...Continue Reading

References

Jul 1, 1979·American Journal of Epidemiology·I B TagerF E Speizer
Jan 1, 1976·The Journal of Pediatrics·S P MorozA Sass-Kortsak
Jun 10, 1976·The New England Journal of Medicine·T Sveger
Jun 1, 1974·Acta Medica Scandinavica·S Eriksson, I Hägerstrand
Jan 31, 1980·The New England Journal of Medicine·J M HoodT E Starzl
Feb 1, 1964·The American Journal of Psychiatry·P CHODOFFD A HAMBURG

❮ Previous
Next ❯

Citations

Nov 1, 1988·Acta paediatrica Scandinavica·T Sveger
Nov 1, 1987·British Journal of Obstetrics and Gynaecology·S H KennedyC W Redman
Nov 1, 1982·Acta paediatrica Scandinavica·A Nemeth, B Strandvik
Mar 3, 2015·European Respiratory Review : an Official Journal of the European Respiratory Society·Noel G McElvaney
Jul 29, 2016·Nature Reviews. Disease Primers·Catherine M GreeneNoel G McElvaney
Jan 1, 1989·Critical Reviews in Clinical Laboratory Sciences·R D Feld
Jan 1, 1987·Journal of Medical Genetics·D W Cox, T Mansfield
Sep 1, 1983·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S AnandD H Van Thiel
Mar 1, 1991·The American Review of Respiratory Disease·E Kerem, A Lynch
Feb 16, 2018·Alimentary Pharmacology & Therapeutics·S A TownsendA M Turner
Feb 8, 2020·Respirology : Official Journal of the Asian Pacific Society of Respirology·Jack DummerAnne E Holland
May 1, 1990·Current Problems in Pediatrics·J E Heubi, C C Daugherty
Jun 23, 2001·Archives of Disease in Childhood·R A Primhak, M S Tanner

❮ Previous
Next ❯

Related Concepts

Related Feeds

Ataxia telangiectasia (MDS)

Ataxia telangiectasia is a rare neurodegenerative diseases caused by defects in the ATM gene, which is involved in DNA damage recognition and repair pathways. Here is the latest research on this autosomal recessive disease.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.