PMID: 558094Apr 1, 1977Paper

Fourth expansion and glucose perturbation of the Dictyostelium kinetic model

European Journal of Biochemistry
B E WrightA Tai

Abstract

The kinetic model of carbohydrate metabolism has been expanded to include: (a) the accumulation of alpha and beta-cellulose, insoluble cell-wall glycogen and mucopolysaccharide; (b) the role of RNA turnover as a source of carbon for end-product synthesis and as a buffer regulating the level of uridine nucleotides in this metabolic network; and (c) the role of purine-nucleoside phosphorylase, 5'-AMP nucleotidase, nucleosidediphosphate kinase and polynucleotide phosphorylase. One of many predictions based on this model is that cells differentiating in the presence of glucose will produce sorocarps with an abnormally high trehalose to cellulose ratio. External perturbation of either the model or of developing cells by glucose increases the levels of sorocarp trehalose and glycogen, 5-fold and 6-fold respectively. Evaluation of the experimental data and the simulation analyses have allowed several predictions to be made concerning the compartmentation of metabolites and the permeability of cells to glucose during differentiation.

References

Oct 1, 1975·Journal of Bacteriology·H V RickenbergJ M Ashworth
Jun 1, 1969·European Journal of Biochemistry·G GerischO Lüderitz
Dec 1, 1969·Biochemistry·P Baumann
Oct 1, 1971·Journal of Bacteriology·C L Rutherford, B E Wright
Feb 9, 1973·Annals of the New York Academy of Sciences·B E WrightR Marshall
Jan 1, 1974·Annual Review of Microbiology·K A Killick, B E Wright
Sep 1, 1974·Archives of Biochemistry and Biophysics·P A Rosness, B E Wright
Jul 21, 1970·Biochemistry·R MarshallB E Wright
Oct 1, 1965·Journal of Cellular Physiology·C Ceccarini, M Filosa
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Jun 1, 1961·Developmental Biology·G U LIDDEL, B E WRIGHT
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Apr 1, 1964·Developmental Biology·B E WRIGHTC WARD
Mar 1, 1965·Journal of General Microbiology·K GEZELIUS, B E WRIGHT

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Citations

Jan 1, 1980·The International Journal of Biochemistry·P J AndersonB E Wright
Mar 1, 1980·Mechanisms of Ageing and Development·B E Wright, P F Davison
May 31, 1991·Journal of Chromatography·B E Wright
Feb 1, 1978·Journal of Bacteriology·K A Killick, B E Wright
Dec 1, 1979·Journal of Bacteriology·R G Emyanitoff, B E Wright

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