Fourth rank immobile nucleic acid junctions

Journal of Biomolecular Structure & Dynamics
N R KallenbachN C Seeman

Abstract

An immobile nucleic acid junction composed of four dodecanucleotides has been designed according to principles of minimum symmetry aided by equilibrium calculations, and has been synthesized by automated phosphotriester techniques. We can demonstrate its tetrameric character and its 1:1:1:1 stoichiometry by gel electrophoresis. Thermal denaturation monitored by ultraviolet hyperchromism indicates that the complex is stable relative to its component arms. High resolution NMR spectroscopy suggests that this junction exists in more than one conformer at room temperature. The data from this junction are compared with the data from a similar junction composed of four hexadecanucleotides.

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Citations

May 24, 1985·Nucleic Acids Research·D E WemmerB R Reid
Dec 22, 1986·Nucleic Acids Research·R I MaN C Seeman
Sep 9, 2015·Archives of Biochemistry and Biophysics·Douglas IversonAnthony J Bell
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Dec 7, 2002·Protein Engineering·Anthony J BellNeville R Kallenbach
Jan 31, 2014·ACS Applied Materials & Interfaces·Sreekantha Reddy DugasaniVijay Manchanda
Oct 16, 2010·Biosensors & Bioelectronics·Abhichart KrissanaprasitWerasak Surareungchai

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