PMID: 15226592Jul 1, 2004Paper

Fourth ventricular alloxan injection suppresses pulsatile luteinizing hormone release in female rats

The Journal of Reproduction and Development
Mika KinoshitaKei-Ichiro Maeda

Abstract

Previous studies have suggested the presence of a glucose-sensing mechanism in the hindbrain that appears to regulate reproductive function as well as feeding behavior. The ependymocytes lining the ventricular wall of the hindbrain showed immunoreactivities to pancreatic glucokinase (GK), a key enzyme for glucose sensing in pancreatic B cells. Our goal in the present study was to test whether the GK-immunopositive ependymocytes in the wall of the fourth cerebroventricle (4V) play a role in regulating gonadal activity. Our approach was to determine the effect of injecting alloxan, a GK inhibitor, into the 4V on pulsatile luteinizing hormone (LH) secretion. Estrogen-primed ovariectomized rats received an injection of alloxan (10 or 20 microg/animal) into the 4V and blood samples were collected every 6 min for 3 h for measurement of blood LH, corticosterone and glucose levels. Pulsatile LH secretion was suppressed after alloxan injection and all pulse parameters were significantly (P<0.05) inhibited by 20 microg alloxan. Plasma corticosterone levels were increased significantly (P<0.05) by 20 microg alloxan, suggesting that LH pulse suppression by alloxan may be at least partly mediated by activation of the hypothalamo-pituitary-a...Continue Reading

References

Apr 19, 1969·Nature·Y OomuraM J Wayner
Nov 1, 1993·The Journal of Clinical Investigation·F MatschinskyT L Jetton
Apr 16, 2003·Hormones and Behavior·Helen I'AnsonKristen R Bonnema

❮ Previous
Next ❯

Citations

Sep 30, 2006·The Journal of Reproduction and Development·Mohammad ShahabKei-ichiro Maeda
Mar 6, 2009·The Journal of Reproduction and Development·Shuichi MatsuyamaKoji Kimura
Aug 5, 2006·Physiology & Behavior·Sue RitterAi-Jun Li
Jan 22, 2019·The Journal of Reproduction and Development·Chikaya DeuraHiroko Tsukamura
Sep 24, 2014·Reproductive Medicine and Biology·Shuichi Matsuyama, Koji Kimura
Mar 13, 2021·General and Comparative Endocrinology·Hiroko Tsukamura

❮ Previous
Next ❯

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.