Foveal cystoid spaces are associated with enlarged foveal avascular zone and microaneurysms in diabetic macular edema

Ophthalmology
Tomoaki MurakamiNagahisa Yoshimura

Abstract

To study the association between pathomorphology at the foveal center delineated by spectral domain optical coherence tomography (SD-OCT) and vascular changes around the fovea in fluorescein angiography (FA) in patients with diabetic macular edema (DME). Retrospective, observational, cross-sectional study. Consecutive series of 86 eyes from 72 patients with clinically significant macular edema (CSME) on which SD-OCT and FA were performed on the same day. Fluorescein angiography using HRA2 (Heidelberg Engineering, Heidelberg, Germany) and SD-OCT images using Spectralis OCT (Heidelberg Engineering) were obtained for all patients. Microaneurysms (MAs) in the perifoveal capillary network (PCN) and foveal avascular zone (FAZ) in the FA images were quantified. The pathomorphology at the foveal center was evaluated in OCT images. We then investigated the association between pathologic perifoveal capillaries in FA and the neuroglial morphology in OCT. The relationship between pathologic changes in perifoveal capillaries in FA and foveal pathomorphology in OCT. According to the foveal morphology in OCT images, 44 eyes presented foveal cystoid spaces (cystoid macular edema [CME]), 25 eyes had serous retinal detachment (SRD) at the foveal...Continue Reading

References

Nov 1, 1974·Experimental Eye Research·A C Bird, R A Weale
May 1, 1984·Survey of Ophthalmology·M YanoffR C Eagle
Sep 1, 1984·Archives of Ophthalmology·G H BresnickK Korth
Aug 1, 1982·Ophthalmology·M O Tso
Oct 1, 1981·American Journal of Ophthalmology·B S Fine, A J Brucker
Jun 1, 1995·Archives of Ophthalmology·T Batchelder, M Barricks
Jan 1, 1993·Retina·A M MansourR Haymond
Jun 1, 1996·Endocrinology and Metabolism Clinics of North America·G L King, M Brownlee
Jun 18, 1999·American Journal of Ophthalmology·T OtaniY Maruyama
Sep 1, 2001·American Journal of Ophthalmology·J B Jonas, A Söfker
Sep 1, 1961·Archives of Ophthalmology·D G COGANT KUWABARA
Sep 1, 1963·The British Journal of Ophthalmology·N ASHTON
Dec 26, 2006·American Journal of Ophthalmology·Tomoaki MurakamiNagahisa Yoshimura
Aug 23, 2007·JAMA : the Journal of the American Medical Association·Quresh MohamedTien Y Wong
Mar 8, 2008·Documenta Ophthalmologica. Advances in Ophthalmology·Maria TyrbergMonica Lövestam-Adrian
Jul 18, 2008·Current Diabetes Reports·Thomas W Gardner, David A Antonetti
May 12, 2009·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Atsushi SakamotoNagahisa Yoshimura

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Citations

Oct 14, 2011·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Pei-Chen WuChien-Neng Kuo
Sep 8, 2012·International Ophthalmology Clinics·Annette Ossewaarde-van Norel, Aniki Rothova
Mar 20, 2012·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Toco Y P ChuiStephen A Burns
Sep 28, 2013·Journal of Diabetes Research·Tomoaki Murakami, Nagahisa Yoshimura
Feb 12, 2013·American Journal of Ophthalmology·Su Na LeeWilliam R Freeman
Jun 15, 2016·PLoS Computational Biology·Xiao FuThomas J Gast
Apr 24, 2018·Acta Ophthalmologica·Suzanne BroadgateVictor Chong
Feb 27, 2019·Japanese Journal of Ophthalmology·Miho NozakiYuichiro Ogura
Feb 27, 2019·Investigative Ophthalmology & Visual Science·Tatsuya YoshitakeAkitaka Tsujikawa
Apr 1, 2011·Saudi Journal of Ophthalmology : Official Journal of the Saudi Ophthalmological Society·Pearse A Keane, Srinivas R Sadda
May 22, 2019·Scientific Reports·Tatsuya YoshitakeAkitaka Tsujikawa
Aug 16, 2017·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Lili HuShuanghong Jiang
May 4, 2018·International Journal of Endocrinology·Yoshihiro TakamuraMasaru Inatani
Mar 11, 2020·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Serra ArfMurat Karacorlu

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