Foveal densitometry as a diagnostic technique in Stargardt's disease

American Journal of Ophthalmology
G J van Meel, D van Norren

Abstract

Foveal densitometry was performed in eight patients with Stargardt's disease. Their visual acuities were between 20/200 and 20/16. All eight had low two-way densities, ranging from 0.07 to less than or equal to 0.01 (mean value for a control group, 0.32 +/- 0.03). Two patients had poor visual acuities combined with ophthalmoscopically normal maculas. Because two-way densities were very low in these patients, ranging between 0.04 and less than or equal to 0.01, foveal densitometry may be a useful diagnostic technique in the diagnosis of Stargardt's disease. Foveal densitometry was also performed in two patients with fundus flavimaculatus and good visual acuities for the sake of comparison. Two-way densities were between 0.09 and 0.24. One patient with cone dystrophy and poor visual acuity had low two-way densities (0.02 bilaterally). Three patients with vitelliform dystrophy and vitelliform cysts on ophthalmoscopy had two-way densities between 0.07 and 0.14 and increased half-times of regeneration (between 90 and 126 seconds). One patient with a vitelliform cyst in one eye showed only fine pigmentations in the other eye, which had a normal two-way density (0.32).

References

Feb 1, 1986·Archives of Ophthalmology·P E KilbrideL P Hutman
Mar 1, 1974·American Journal of Ophthalmology·J T PearlmanJ J Sheppard
Jan 1, 1974·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·J FrançoisE Cambie
Apr 16, 1973·Documenta Ophthalmologica. Advances in Ophthalmology·A E KrillM Fishman
Nov 1, 1972·The British Journal of Ophthalmology·A R Irvine, F L Wergeland
Sep 15, 1984·American Journal of Ophthalmology·G J van MeelD van Norren
Jul 1, 1982·Archives of Ophthalmology·T A WeingeistR C Watzke
Aug 1, 1963·Archives of Ophthalmology·G GOODMANI M SIEGEL

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Citations

Jan 1, 1989·Vision Research·D van Norren, J van de Kraats
Oct 1, 1995·Journal of the Optical Society of America. A, Optics, Image Science, and Vision·W H Swanson, G E Fish
Dec 1, 1989·Documenta Ophthalmologica. Advances in Ophthalmology·P LachapelleM S Roy
Jun 1, 1994·The British Journal of Ophthalmology·W BacaA M Glenn
Jun 1, 1989·The British Journal of Ophthalmology·W SeipleR Carr
Oct 1, 1992·The British Journal of Ophthalmology·J P ter BruggenD van Norren
Dec 21, 2000·Clinical Otolaryngology and Allied Sciences·C F SmitD Kupperman

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