PMID: 7542915Jun 1, 1995Paper

Foveal electroretinograms and choroidal perfusion characteristics in fellow eyes of patients with unilateral neovascular age-related macular degeneration

The British Journal of Ophthalmology
J F RemullaM A Sandberg

Abstract

A prolonged choroidal filling phase on fluorescein angiography has been reported to be a common finding and associated with visual function abnormalities in patients with age-related macular degeneration (AMD). This investigation was carried out to determine whether this perfusion defect was related to the slowing of foveal cone electroretinogram (ERG) implicit time seen in patients with AMD. Fluorescein angiograms and foveal cone ERGs were evaluated in the fellow eyes of 67 patients with unilateral neovascular AMD. Twenty eight (42%) of the eyes had a choroidal perfusion defect. ERG implicit times averaged 1 ms slower (p = 0.0167) and were more likely to be delayed (p = 0.0078) in eyes with abnormal choroidal perfusion than in eyes with normal choroidal filling; significant relations were found also after controlling for age. ERG implicit time was also inversely related to ETDRS visual acuity and positively related to the extent of macular drusen; and the latter showed a borderline significant tendency to be more prevalent in eyes with prolonged choroidal perfusion. However, an association of a delayed ERG implicit time with prolonged choroidal filling remained after controlling for age, acuity, and the extent of drusen. These...Continue Reading

References

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Citations

Mar 17, 2010·Documenta Ophthalmologica. Advances in Ophthalmology·Emma J BerrowJonathan M Gibson
Oct 31, 1998·Harvard Women's Health Watch
Apr 4, 2001·Acta Ophthalmologica Scandinavica·T A CiullaB J Martin
Jan 30, 2002·The British Journal of Ophthalmology·Thomas A CiullaHanna J Garzozi
Jun 27, 2002·The British Journal of Ophthalmology·G DimitrovaM Nagahara
Mar 11, 2005·Expert Opinion on Emerging Drugs·Grant M ComerMark H Criswell
Apr 14, 2010·Survey of Ophthalmology·Galina Dimitrova, Satoshi Kato
Nov 1, 2005·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Beatrix FeiglBrian Brown
Apr 4, 2006·Progress in Retinal and Eye Research·R E Hogg, U Chakravarthy
May 31, 2016·Acta Histochemica Et Cytochemica·Katsunori NochiokaAkio Wanaka
Jun 8, 2007·Ophthalmic Surgery, Lasers & Imaging : the Official Journal of the International Society for Imaging in the Eye·Ehud RechtmanThomas A Ciulla
Oct 8, 1998·Survey of Ophthalmology·T A CiullaA Harris

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