Fowl adenovirus serotype 4-induced apoptosis, autophagy, and a severe inflammatory response in liver

Veterinary Microbiology
Yujuan NiuSidang Liu

Abstract

Fowl adenovirus serotype 4 (FAdV-4) is a hepatotrophic virus that causes severe liver diseases. Upon histological examination, the most remarkable findings in the liver are small multifocal areas of necrosis and mononuclear cell infiltration, including basophilic intranuclear inclusion bodies in hepatocytes surrounded by a clear halo or which fill the entire nucleus. Here, we examined the mechanism responsible for FAdV-4-mediated hepatocyte damage in vivo and in vitro. The results showed that FAdV-4 impaired liver integrity and function, which decreased albumin and blood glucose concentrations and increased the plasma activity of aspartate aminotransferase and lactate dehydrogenase, compared with a non-infected control group (P<0.05). FAdV-4 induced hepatocyte apoptosis in a time-dependent manner in vivo and in vitro. Additionally, we found that FAdV-4 also induced the autophagy of hepatocytes, which promoted the conversion of microtubule-associated protein light chain 3 (LC3-I) to LC3-II, which is a hallmarks of autophagy. Furthermore, the mRNA expressions of interleukin (IL)-1β, IL-6, IL-8, and tumor necrosis factor (TNF)-α in vivo and in vitro showed a statistically significant increase (P<0.05) compared to that of the contr...Continue Reading

Citations

Jun 4, 2019·Avian Pathology : Journal of the W.V.P.A·Zhipeng WeiYouxiang Diao
Aug 28, 2019·Viruses·Hai-Chang YinTian-Fei Yu
Jul 21, 2020·Autophagy·Sophie TesseraudIban Seiliez
May 23, 2020·Biological Trace Element Research·Yue WangJianzhu Liu
Dec 22, 2020·Frontiers in Veterinary Science·Yudong YangNing Li
Apr 18, 2019·Poultry Science·Yujuan NiuSidang Liu
Jul 25, 2021·Cancers·Margarita KamyninaIlya Ulasov

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