FOXA2 depletion leads to mucus hypersecretion in canine airways with respiratory diseases

Cellular Microbiology
Woosuk ChoiGee W Lau

Abstract

Because of exposure to environmental pollutants, infectious agents, and genetic predisposition, companion animals develop respiratory illnesses similar to those in humans. Older dogs of smaller breeds develop canine infectious respiratory disease, chronic bronchitis, and chronic obstructive pulmonary disease, with chronic lung infection, airway goblet cell hyperplasia and metaplasia, and mucus hypersecretion. Excessive mucus clogs airways, reduces gas exchanges, disables the mucociliary clearance, and reduces drug penetration. The Forkhead box protein A2 (FOXA2) is a key transcriptional regulator that maintains airway mucus homeostasis. Prior studies have shown that FOXA2 expression is frequently depleted in diseased human airways. Unfortunately, FOXA2 depletion has not been examined in dogs. Our current study indicated that both single bacterial infection by Pseudomonas aeruginosa and Bordetella bronchiseptica and polymicrobial infection by viral/bacterial pathogens depleted FOXA2 in canine airways, resulting in goblet cell hyperplasia and metaplasia and excessive mucus production. Furthermore, P. aeruginosa virulence factor pyocyanin activated the antagonistic STAT6 and epidermal growth factor receptor signalling pathways to ...Continue Reading

References

May 18, 1974·The Veterinary Record·E B WheeldonR Lee
Nov 1, 1984·The Journal of Clinical Investigation·J D KlingerT F Boat
Nov 1, 1994·European Journal of Biochemistry·N Osherov, A Levitzki
May 20, 1998·Proceedings of the National Academy of Sciences of the United States of America·J D LiC Basbaum
Aug 2, 2001·Proceedings of the National Academy of Sciences of the United States of America·N McNamaraC Basbaum
Jul 2, 2002·American Journal of Respiratory and Critical Care Medicine·Erwin W Gelfand
Jul 2, 2002·American Journal of Respiratory and Critical Care Medicine·Carl G A Persson
Nov 27, 2002·The European Respiratory Journal·K KohriJ A Nadel
Feb 6, 2004·Development·Huajing WanJeffrey A Whitsett
Jun 24, 2004·Infection and Immunity·Gee W LauDimitri Mavrodi
Nov 30, 2004·Trends in Molecular Medicine·Gee W LauFansheng Kong
Jul 21, 2005·Journal of Bacteriology·Kelli L PalmerMarvin Whiteley
Dec 24, 2005·Physiological Reviews·Mary Callaghan Rose, Judith A Voynow
Jan 3, 2006·The Journal of Allergy and Clinical Immunology·Dominik HartlSusanne Krauss-Etschmann
Sep 19, 2006·American Journal of Respiratory Cell and Molecular Biology·Guohua ZhenDavid J Erle
Mar 10, 2007·The Journal of Clinical Investigation·Kwon-Sik ParkJeffrey A Whitsett
May 25, 2007·BMC Microbiology·Joanne L FothergillCraig Winstanley
Sep 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jose R CortesJose Zamorano
Jan 2, 2009·The European Respiratory Journal·C M LunaA Torres
Jun 13, 2009·American Journal of Respiratory Cell and Molecular Biology·David R Curran, Lauren Cohn
Jun 18, 2009·Current Opinion in Pulmonary Medicine·Timothy F Murphy
Jul 25, 2009·American Journal of Respiratory and Critical Care Medicine·Sung-Woo ParkDavid J Erle
Nov 7, 2009·The American Journal of Pathology·Charles C CaldwellGee W Lau
May 21, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Gang ChenJeffrey A Whitsett
Jun 24, 2010·The Veterinary Journal·Simon Priestnall, Kerstin Erles
Aug 21, 2010·Respirology : Official Journal of the Asian Pacific Society of Respirology·Bryan J WilliamsTimothy S Blackwell
Dec 3, 2010·The New England Journal of Medicine·John V Fahy, Burton F Dickey
Feb 9, 2012·International Journal of Chronic Obstructive Pulmonary Disease·Stephanie A TuckJoseph C Anderson
Aug 7, 2012·American Journal of Respiratory Cell and Molecular Biology·Ryan C HunterDianne K Newman
Apr 10, 2013·Current Opinion in Pharmacology·Malcolm Ronald StarkeyPhilip Michael Hansbro
Jul 5, 2013·American Journal of Respiratory Cell and Molecular Biology·Xiaoju TangFengming Luo
Aug 7, 2013·Respiratory Research·Yonghua HaoGee W Lau
Nov 26, 2013·The Veterinary Clinics of North America. Small Animal Practice·Elizabeth Rozanski
Nov 26, 2013·The Veterinary Clinics of North America. Small Animal Practice·Jonathan D Dear
Dec 10, 2013·Nature·Michelle G RoyChristopher M Evans
Dec 25, 2013·Annals of the American Thoracic Society·Jesse RomanUNKNOWN ATS Comparative Biology of Lung Fibrosis Working Group
Mar 26, 2014·Tissue Barriers·Shyamala GanesanUma S Sajjan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.