Foxc1 is required for early stage telencephalic vascular development

Developmental Dynamics : an Official Publication of the American Association of Anatomists
Thanit PrasitsakSachiko Iseki

Abstract

The brain vascular system arises from the perineural vascular plexus (PNVP) which sprouts radially into the neuroepithelium and subsequently branches off laterally to form a secondary plexus in the subventricular zone (SVZ), the subventricular vascular plexus (SVP). The process of SVP formation remains to be fully elucidated. We investigated the role of Foxc1 in early stage vascular formation in the ventral telencephalon. The Foxc1 loss of function mutant mouse, Foxc1(ch/ch) , showed enlarged telencephalon and hemorrhaging in the ventral telencephalon by embryonic day 11.0. The mutant demonstrated blood vessel dilation and aggregation of endothelial cells in the SVZ after the invasion of endothelial cells through the radial path, which lead to failure of SVP formation. During this early stage of vascular development, Foxc1 was expressed in endothelial cells and pericytes, as well as in cranial mesenchyme surrounding the neural tube. Correspondingly, abnormal deposition pattern of basement membrane proteins around the vessels and increased strong Vegfr2 staining dots were found in the aggregation sites. These observations reveal an essential role for Foxc1 in the early stage of vascular formation in the telencephalon.

References

May 2, 2001·The Journal of Cell Biology·M HellströmC Betsholtz
Sep 18, 2004·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Holger GerhardtChrister Betsholtz
Aug 24, 2007·Proceedings of the National Academy of Sciences of the United States of America·Konstantinos ZarbalisSamuel J Pleasure
Jan 12, 2008·Biochemical and Biophysical Research Communications·Hisaki Hayashi, Tsutomu Kume
Jul 12, 2008·Mechanisms of Development·Toshiyuki YoshidaSachiko Iseki
Dec 20, 2008·Lymphatic Research and Biology·Michael R MancusoCalvin J Kuo
Jan 9, 2009·Proceedings of the National Academy of Sciences of the United States of America·Richard DanemanBen A Barres
Mar 6, 2009·Cell Adhesion & Migration·Anju Vasudevan, Pradeep G Bhide
Mar 11, 2009·Nature Reviews. Genetics·Sridhar Hannenhalli, Klaus H Kaestner
May 22, 2009·Investigative Ophthalmology & Visual Science·Jonathan M Skarie, Brian A Link
Aug 31, 2011·Laboratory Investigation; a Journal of Technical Methods and Pathology·Ha-Long NguyenS Paul Oh
Sep 20, 2011·Cell·Michael PotentePeter Carmeliet
Dec 16, 2011·Proceedings of the National Academy of Sciences of the United States of America·Seungwoon SeoTsutomu Kume
Oct 23, 2012·Cold Spring Harbor Perspectives in Medicine·Raquel Blanco, Holger Gerhardt
Nov 20, 2012·Development, Growth & Differentiation·Emiko YamanishiNoriko Osumi
Mar 12, 2013·Cellular and Molecular Life Sciences : CMLS·Christiana Ruhrberg, Victoria L Bautch
Jul 19, 2013·Biology Open·Julie A SiegenthalerSamuel J Pleasure

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.

Related Papers

Developmental Dynamics : an Official Publication of the American Association of Anatomists
Holger GerhardtChrister Betsholtz
Mechanisms of Development
Mitsunari NakajimaTakuji Shirasawa
Developmental Dynamics : an Official Publication of the American Association of Anatomists
Jamie A Havrilak, John M Shannon
© 2022 Meta ULC. All rights reserved