FOXC1, the new player in the cancer sandbox

Oncotarget
Fahed A ElianM A Walter

Abstract

In recent years, rapidly accumulating evidence implicates forkhead box C1 (FOXC1) in cancer, especially in studies of basal-like breast cancer (BLBC). Other studies have followed suit, demonstrating thatFOXC1is not only a major player in this breast cancer subtype, but also in hepatocellular carcinoma (HCC), endometrial cancer, Hodgkin's lymphoma (HL), and non-Hodgkin's lymphoma (NHL). TheFOXC1gene encodes a transcription factor that is crucial to mesodermal, neural crest, and ocular development, and mutations found inFOXC1have been found to cause dominantly inherited Axenfeld-Rieger Syndrome (ARS). Interestingly, whileFOXC1missense mutations that are associated with ARS usually reduce gene activity, increasedFOXC1function now appears to be often linked to more aggressive cancer phenotypes in BLBC, HCC, HL, and NHL. This review discusses not only the role ofFOXC1in cancer cell progression, proliferation, differentiation, and metastasis, but also the underlying mechanisms of howFOXC1can contribute to aggressive cancer phenotypes.

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Citations

Feb 6, 2019·Nucleic Acids Research·Xiaojuan ChenYongheng Chen
Jul 22, 2020·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Hui Li, Junhong Jiang
Aug 3, 2019·Molecular Diagnosis & Therapy·Nadana SabapathiRama Jayaraj
Oct 27, 2018·International Journal of Molecular Sciences·Duc-Hiep BachSang Kook Lee
May 31, 2018·Investigative Ophthalmology & Visual Science·Lance P DoucetteMichael A Walter
Mar 18, 2021·Biochimica Et Biophysica Acta. Gene Regulatory Mechanisms·Mudasir RashidSanjay Gupta
May 14, 2021·Frontiers in Pharmacology·Yanan LiuHuanhai Xu
May 24, 2020·Experimental and Molecular Pathology·Peng JingDan Zhao

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Methods Mentioned

BETA
chromosomal aberrations
ubiquitination

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