FOXF1 transcription factor promotes lung morphogenesis by inducing cellular proliferation in fetal lung mesenchyme

Developmental Biology
Vladimir UstiyanV V Kalinichenko

Abstract

Organogenesis is regulated by mesenchymal-epithelial signaling events that induce expression of cell-type specific transcription factors critical for cellular proliferation, differentiation and appropriate tissue patterning. While mesenchymal transcription factors play a key role in mesenchymal-epithelial interactions, transcriptional networks in septum transversum and splanchnic mesenchyme remain poorly characterized. Forkhead Box F1 (FOXF1) transcription factor is expressed in mesenchymal cell lineages; however, its role in organogenesis remains uncharacterized due to early embryonic lethality of Foxf1-/- mice. In the present study, we generated mesenchyme-specific Foxf1 knockout mice (Dermo1-Cre Foxf1-/-) and demonstrated that FOXF1 is required for development of respiratory, cardiovascular and gastrointestinal organ systems. Deletion of Foxf1 from mesenchyme caused embryonic lethality in the middle of gestation due to multiple developmental defects in the heart, lung, liver and esophagus. Deletion of Foxf1 inhibited mesenchyme proliferation and delayed branching lung morphogenesis. Gene expression profiling of micro-dissected distal lung mesenchyme and ChIP sequencing of fetal lung tissue identified multiple target genes ac...Continue Reading

Citations

Feb 20, 2020·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jinghui GaoAmy L Ryan
Oct 31, 2019·Journal of Medical Genetics·Laurie A SteinerKristin Scheible
Apr 3, 2020·American Journal of Respiratory and Critical Care Medicine·Craig BolteVladimir V Kalinichenko
Jan 12, 2021·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Enhong LiVladimir V Kalinichenko
Sep 3, 2020·American Journal of Respiratory and Critical Care Medicine·Bingqiang WenVladimir V Kalinichenko
Oct 24, 2020·American Journal of Respiratory Cell and Molecular Biology·Zicheng DengVladimir V Kalinichenko
Apr 12, 2021·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Hirofumi Kiyokawa, Mitsuru Morimoto
Mar 12, 2021·American Journal of Respiratory and Critical Care Medicine·Guolun WangVladimir V Kalinichenko
Nov 14, 2020·Current Stem Cell Reports·Arun PradhanVladimir V Kalinichenko
Sep 16, 2021·Physiological Reports·Shelby ThomasBrenda Lilly
Jul 23, 2021·American Journal of Respiratory Cell and Molecular Biology·Olena A KolesnichenkoVladimir V Kalinichenko

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