FOXM1: A novel drug target in gastroenteropancreatic neuroendocrine tumors

Oncotarget
Franziska BriestPatricia Grabowski

Abstract

Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) are heterogeneous tumors that need to be molecularly defined to obtain novel therapeutic options. Forkheadbox protein M1 (FOXM1) is a crucial transcription factor in neoplastic cells and has been associated with differentiation and proliferation. We found that FOXM1 is strongly associated with tumor differentiation and occurrence of metastases in gastrointestinal NENs. In vitro inhibition by the FOXM1 inhibitor siomycin A led to down-regulation of mitotic proteins and resulted in a strong inhibitory effect. Siomycin A decreased mitosis rate, induced apoptosis in GEP-NEN cell lines and exerts synergistic effects with chemotherapy. FOXM1 is associated with clinical outcome and FOXM1 inhibition impairs survival in vitro. We therefore propose FOXM1 as novel therapeutic target in GEP-NENs.

References

Oct 16, 1999·The Journal of Biological Chemistry·C P Lim, X Cao
May 28, 2005·Proceedings of the National Academy of Sciences of the United States of America·Ling LiuNancy C Reich
Jun 17, 2005·Cancer Research·Diane R Wonsey, Maximillian T Follettie
Mar 16, 2006·The Journal of Clinical Endocrinology and Metabolism·Irvin M ModlinManish C Champaneria
Oct 5, 2006·Cancer Research·Senthil K RadhakrishnanAndrei L Gartel
Feb 26, 2008·Nature Reviews. Cancer·Stephen S Myatt, Eric W-F Lam
Mar 28, 2008·Cell Research·Jinbo Yang, George R Stark
May 15, 2009·PloS One·Uppoor G BhatAndrei L Gartel
Aug 13, 2009·PloS One·Uppoor G BhatAndrei L Gartel
Dec 22, 2009·Cancer Treatment Reviews·Zhiwei WangFazlul H Sarkar
Jan 16, 2010·Expert Opinion on Investigational Drugs·Andrei L Gartel
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
Mar 30, 2011·Current Drug Targets·Miranda S C WilsonEric W-F Lam
Oct 8, 2011·Biochimica Et Biophysica Acta·Chuay-Yeng KooEric W-F Lam
Mar 14, 2012·Future Oncology·Yu LiSuyun Huang
Jul 4, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Katharina FraedrichDaniel Benten
Sep 15, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Nu ZhangSuyun Huang
Oct 2, 2012·Cancer Letters·Masuko KatohMasaru Katoh
Oct 30, 2012·Biochemical Pharmacology·Marianna Halasi, Andrei L Gartel
Nov 6, 2012·Frontiers of Medicine·Fung Zhao, Eric W-F Lam
Nov 22, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Nuo XuChun-Xue Bai
Jan 18, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Dongye LiuChui-ze Kong
Feb 28, 2013·Molecular Cancer Therapeutics·Marianna Halasi, Andrei L Gartel
Jun 26, 2013·Nature Reviews. Cancer·Eric W-F LamChuay-Yeng Koo

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Citations

May 22, 2020·The Oncologist·Enrique GrandeTeresa Alonso-Gordoa
Jun 14, 2019·World Journal of Pediatrics : WJP·Li Gu, Han-Min Liu
Aug 22, 2020·World Journal of Gastroenterology : WJG·Gabriel Benyomo MpillaAsfar Sohail Azmi
Dec 22, 2016·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Mayumi EgawaTetsuo Takehara
Mar 12, 2016·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Ellinor AnderssonOla Nilsson

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Methods Mentioned

BETA
flow cytometry
biopsies

Software Mentioned

BD Cell Quest Pro
CompuSyn
SPSS Statistics
FlowJo
Multi Gauge

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