FoxM1 Directs STAT3 Expression Essential for Human Endometrial Stromal Decidualization

Scientific Reports
Yaling JiangHaibin Wang

Abstract

Human endometrium decidualization, which involves endometrial stromal proliferation and differentiation, is a prerequisite for embryo implantation, thus successful pregnancy. The Forkhead Box M1 (FoxM1), previously known as HNF-3, HFH-11, MPP2, Win, and Trident, is a transcriptional factor that plays crucial roles in cell proliferation and cell cycle progression. However, the molecular mechanism of FoxM1 during human endometrial decidualization remains unexplored. In this study, we first found FoxM1 is dynamically expressed in human endometrium during menstrual cycle. Employing a human endometrial stromal cell (HESC) line, we then demonstrated that FoxM1 inhibition downregulates cyclin B1 expression, delaying G2/M phase transition during HESC proliferation. Additionally, loss of FoxM1 expression blocks the differentiation of HESCs in response to estrogen, progesterone, and dbcAMP. Applying chromatin immunoprecipitation (ChIP) technique and luciferase assay, we further approved that FoxM1 can transcriptionally active signal transducer and activator of transcription 3 (STAT3), ensuring normal HESC differentiation. Besides enriching our knowledge on molecular basis underlying stromal decidualization, these findings help to shed li...Continue Reading

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Citations

Jan 26, 2016·American Journal of Reproductive Immunology : AJRI·Arpita S BhurkeMilan K Bagchi
May 31, 2016·Journal of Pregnancy·Kameliya VinketovaTsvetelina Oreshkova
Dec 21, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Pavle VrljicakSascha Ott
Feb 9, 2017·Medical Oncology·Xin SongYuanliang Gu
Jan 27, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Li-Juan ChenHao Zhou
Apr 19, 2021·Fertility and Sterility·Rohan R ChodankarHilary O D Critchley
Dec 2, 2020·Ecotoxicology and Environmental Safety·Sitong YaoYongjiang Ma

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Methods Mentioned

BETA
transgenic
PCR
flow cytometry
immunoprecipitation
electrophoresis
Assay
biopsies

Software Mentioned

Quantity One
HSCORE

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