FOXO-independent suppression of programmed cell death by the PI3K/Akt signaling pathway in Drosophila

Development Genes and Evolution
Yanling Liu, Michael Lehmann

Abstract

Signaling through the PI3K/Akt/FOXO pathway plays an important role in vertebrates in protecting cells from programmed cell death. PI3K and Akt have been similarly shown to be involved in survival signaling in the invertebrate model organism Drosophila. However, it is not known whether PI3K and Akt execute this function by controlling a pro-apoptotic activity of Drosophila FOXO. In this study, we show that elevated signaling through PI3K and Akt can prevent developmentally controlled death in the salivary glands of the fruit fly. We further show that Drosophila FOXO is not required for normal salivary gland death and that the rescue of salivary gland death by PI3K occurs independent of FOXO. These results give support to the notion that FOXOs have acquired pro-apoptotic functions after separation of the vertebrate and invertebrate lineages.

References

May 28, 1998·Current Biology : CB·B E StaveleyA S Manoukian
Dec 2, 1999·Genes & Development·S R DattaM E Greenberg
Dec 10, 1999·Nature Cell Biology·J VerduM J Birnbaum
Dec 2, 2000·Science·D J Klionsky, S D Emr
Apr 26, 2002·Cell Death and Differentiation·M LehmannC S Thummel
Jul 13, 2002·Trends in Biochemical Sciences·Boudewijn M T Burgering, Geert J P L Kops
Sep 20, 2002·Nature·Geert J P L KopsBoudewijn M T Burgering
Feb 1, 2003·Trends in Cell Biology·Sean Oldham, Ernst Hafen
Feb 21, 2003·Current Biology : CB·Cheng-Yu LeeEric H Baehrecke
Feb 21, 2003·Current Biology : CB·Sharon M GorskiMarco A Marra
Jul 8, 2003·BMC Developmental Biology·Jamie M KramerBrian E Staveley
Dec 4, 2003·Current Opinion in Cell Biology·Andreas BergmannMayank Srivastava
May 8, 2004·Trends in Biochemical Sciences·Derek P BrazilBrian A Hemmings
May 20, 2004·Proceedings of the National Academy of Sciences of the United States of America·Viravuth P Yin, Carl S Thummel
Aug 7, 2004·Developmental Cell·Ryan C ScottThomas P Neufeld
Dec 17, 2005·Genome Biology·Robert B BecksteadCarl S Thummel

❮ Previous
Next ❯

Citations

Sep 3, 2009·Journal of Agricultural and Food Chemistry·Subhendu MukherjeeDipak K Das
Jan 13, 2012·American Journal of Physiology. Cell Physiology·Olutayo OdusanwoOlga J Baker
Dec 19, 2006·Journal of Zhejiang University. Science. B·Zhen-qi ZhouFang-xiong Shi
Sep 2, 2008·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Shinji NagataHiromichi Nagasawa
May 29, 2016·The Biochemical Journal·Joëlle Dupont, Rex J Scaramuzzi
Mar 7, 2007·The Journal of Cell Biology·Chike CaoMichael Lehmann
Nov 21, 2019·Cell Death and Differentiation·Tianqi XuSharad Kumar
Nov 28, 2020·Developmental and Comparative Immunology·Xiaoli KangZhongyan Lu

❮ Previous
Next ❯

Related Concepts

Related Feeds

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis