FOXO1 inactivation induces cisplatin resistance in bladder cancer

Cancer Science
Hiroki IdeHiroshi Miyamoto

Abstract

We found that FOXO1-shRNA sublines or FOXO1-positive cells co-treated with a FOXO1 inhibitor were significantly more resistant to cisplatin treatment at pharmacological concentrations, compared with respective control sublines or those with mock treatment. Western blot demonstrated considerable increases in the expression levels of a phosphorylated inactive form of FOXO1 (p-FOXO1) in cisplatin-resistant sublines established by long-term culture with low/increasing doses of cisplatin, compared with respective controls. Immunohistochemistry in surgical specimens from patients with muscle-invasive bladder cancer undergoing cisplatin-based neoadjuvant therapy further showed a strong trend to associate between p-FOXO1 positivity and unfavorable response to chemotherapy.

References

Mar 19, 2009·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Wei-Chien Huang, Mien-Chie Hung
Apr 17, 2013·Nature Reviews. Urology·Iawen HsuShuyuan Yeh
Mar 24, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Matthew I MilowskyCheryl T Lee
Jun 28, 2017·Molecular and Cellular Endocrinology·Satoshi InoueHiroshi Miyamoto
Jan 21, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Lei PengGuoxin Zhang
Feb 8, 2020·Endocrine-related Cancer·Hiroki IdeHiroshi Miyamoto

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Citations

Apr 3, 2021·Frontiers in Endocrinology·Takuro Goto, Hiroshi Miyamoto

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Methods Mentioned

BETA
acetylation

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