FOXO1 is a tumor suppressor in classical Hodgkin lymphoma.

Blood
Linka XieThomas Wirth

Abstract

The FOXO transcription factors control proliferation and apoptosis in different cell types. Their activity is regulated by posttranslational modifications, mainly by the PI3K-PKB pathway, which controls nuclear export and degradation. We show that FOXO1 is highly expressed in normal germinal center B cells as well as in non-Hodgkin lymphomas, including follicular lymphoma, diffuse large B-cell lymphoma, mucosa-associated lymphoid tissue non-Hodgkin lymphoma, B-cell chronic lymphocytic leukemia, and mantle cell lymphoma. In contrast, in 31 of 32 classical Hodgkin lymphoma (cHL) cases, Hodgkin and Reed-Sternberg cells were FOXO1 negative. Neoplastic cells of nodular lymphocyte-predominant Hodgkin lymphoma were negative in 14 of 20 cases. FOXO1 was down-regulated in cHL cell lines, whereas it was expressed in non-Hodgkin lymphoma cell lines at levels comparable with normal B cells. Ectopic expression of a constitutively active FOXO1 induced apoptosis in cHL cell lines and blocked proliferation, accompanied with cell-cycle arrest in the G(0)/G(1) phase. We found that, in cHL cell lines, FOXO1 is inactivated by multiple mechanisms, including constitutive activation of AKT/PKB and MAPK/ERK kinases and up-regulation of microRNAs miR-9...Continue Reading

References

May 30, 2003·Journal of Leukocyte Biology·Boudewijn M T Burgering, René H Medema
Aug 27, 2003·Genes, Chromosomes & Cancer·Daniel T Y ChuiRuth F Jarrett
Nov 2, 2004·Nature Reviews. Immunology·Paul J Coffer, Boudewijn M T Burgering
Dec 9, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Xiaocui ZhuSangdun Choi
Feb 24, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jing ChenDavid A Fruman
Aug 5, 2006·Cell Death and Differentiation·P ObexerM J Ausserlechner
May 19, 2007·The Journal of Biological Chemistry·Robert J SouthgateMark A Febbraio
Nov 3, 2007·Genes & Development·Caroline BouchardClemens A Schmitt
Dec 20, 2007·Blood·Alfons NavarroMariano Monzo
Dec 22, 2007·Nature Reviews. Immunology·Ulf Klein, Riccardo Dalla-Favera
Jan 22, 2008·Nature Cell Biology·Jer-Yen YangMien-Chie Hung
Feb 7, 2008·Cytogenetic and Genome Research·A MaderP Moller
Apr 9, 2008·Oncogene·D R Calnan, A Brunet
Feb 19, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Merry Y ZhaoX Frank Zhao
Feb 27, 2009·The Journal of Biological Chemistry·Ahmed EssaghirJean-Baptiste Demoulin
May 19, 2009·Trends in Immunology·Heike SchmidlinBianca Blom
Jul 4, 2009·The Journal of Biological Chemistry·Irene K Guttilla, Bruce A White
Nov 3, 2009·Cell·Lakshmi SrinivasanKlaus Rajewsky
Jan 23, 2010·Genes, Chromosomes & Cancer·Takahiro KojimaKazuhiko Uchida
Oct 12, 2010·Nature Immunology·Anna-Barbara StittrichMir-Farzin Mashreghi
Nov 19, 2010·British Journal of Haematology·Simon D WagnerPaul Ko Ferrigno
Jan 6, 2011·Proceedings of the National Academy of Sciences of the United States of America·Yu-Wen SuTak W Mak

❮ Previous
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Citations

Sep 12, 2013·Pathology, Research and Practice·Jun-Ichiro IkedaEiichi Morii
Jul 26, 2013·Nature Reviews. Immunology·Robert C Rickert
Oct 24, 2012·The Journal of Experimental Medicine·Marc SeifertRalf Küppers
Aug 21, 2013·PloS One·Benedikta S HaflidadóttirYvonne Ceder
Nov 22, 2013·PloS One·Annika FendlerGeorge M Yousef
Feb 11, 2014·Nature Chemical Biology·Sai Pradeep VelagapudiMatthew D Disney
Mar 13, 2014·The Journal of Clinical Investigation·Yuanzhi LuXianghong Zou
May 9, 2014·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·F XuB Qian
Mar 7, 2013·Cellular and Molecular Life Sciences : CMLS·Ali Hashemi GheinaniKatia Monastyrskaya
Feb 18, 2016·Scientific Reports·Xing ChenQionghai Dai
Jun 1, 2013·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Conghai FanLei Zhang
Dec 22, 2015·Cellular and Molecular Life Sciences : CMLS·Alexandra Coomans de Brachène, Jean-Baptiste Demoulin
Jul 18, 2015·Redox Biology·Lars-Oliver KlotzMaria Monsalve
Jan 29, 2013·International Journal of Cancer. Journal International Du Cancer·Yi QuXi-Song Ke
Jul 22, 2014·Genes, Chromosomes & Cancer·Stefan NagelRoderick A F MacLeod
Sep 4, 2014·European Journal of Oral Sciences·Jianghong GaoLiping Gao
Aug 12, 2014·CA: a Cancer Journal for Clinicians·Ioana Berindan-NeagoeGeorge A Calin
Nov 26, 2015·Scientific Reports·Xi ChenXuerong Wang
Nov 17, 2015·Scientific Reports·Peng TanFeng Li
May 30, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Song-Feng ZhaoQuan-Cheng Kan
Jun 27, 2014·Oxidative Medicine and Cellular Longevity·Nancy P Gómez-CrisóstomoSelva Rivas-Arancibia
Mar 15, 2014·Journal of Skin Cancer·Matthew S NingThomas Andl
Mar 6, 2013·Blood·Diane L TrinhMarco A Marra
Aug 9, 2016·Seminars in Hematology·Stephan MathasRalf Küppers
Aug 16, 2016·Biochemical and Biophysical Research Communications·Bingyu WangTao Xi
May 4, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Xin LuoYuan Yuan

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