FoxP3(+) and IL-17(+) cells are correlated with improved prognosis in cervical adenocarcinoma

Cancer Immunology, Immunotherapy : CII
Simone PuntEkaterina S Jordanova

Abstract

Cervical adenocarcinoma comprises approximately 15 % of cervical cancer cases. This histological subtype has different characteristics than cervical squamous cell carcinoma, which may influence disease progression. To study whether the infiltration of T cell subpopulations was correlated with cervical adenocarcinoma patient survival, similar to squamous cell carcinoma, the tumor-infiltrating T cells, Tregs, Th17 cells and IL-17(+) cell frequencies were analyzed in a cohort of cervical adenocarcinoma patients (n = 67). Intraepithelial, stromal and total cell frequencies were scored using triple immunofluorescence. The majority of Tregs were present in the tumor stroma, while other T cells and IL-17(+) cells infiltrated the tumor epithelium three times more frequently. A high total number of Tregs were significantly correlated with improved disease-specific and disease-free survival (p = 0.010, p = 0.007). Within the tumor epithelium, a high T cell frequency was significantly correlated with improved disease-free survival (p = 0.034). In particular, a low number of both Tregs and IL-17(+) cells were correlated with poor disease-specific survival (p = 0.007). A low number of Tregs combined with Th17 cells present were also correla...Continue Reading

References

Feb 12, 1998·The New England Journal of Medicine·G Y HoR D Burk
Aug 19, 1999·The Journal of Pathology·J M WalboomersN Muñoz
Mar 7, 2001·Lancet·F Balkwill, A Mantovani
Oct 30, 2004·International Journal of Cancer. Journal International Du Cancer·Saskia BulkChris J L M Meijer
Dec 8, 2004·Gynecologic Oncology·Stephen A ContagEric S Calhoun
Jan 24, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Cécile BadoualEric Tartour
Jun 20, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Qiang GaoZhao-You Tang
Sep 4, 2007·Current Opinion in Immunology·Estelle BettelliVijay K Kuchroo
Apr 3, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ekaterina S JordanovaGert Jan Fleuren
Jun 20, 2008·Nature·Estelle BettelliVijay K Kuchroo
Jul 12, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Giuseppe PerroneFrancesco Graziano
Dec 10, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Paul SalamaBarry Iacopetta
Nov 3, 2009·Gynecologic Oncology·Lilian T GienGillian Thomas
Mar 31, 2010·Cancer Immunology, Immunotherapy : CII·Yuqiang Ji, Wanggang Zhang
Jan 15, 2011·International Journal of Biological Sciences·Ju-gao ChenQiao Li
Jun 7, 2011·Cancer Immunology, Immunotherapy : CII·Sylvain LadoireFrançois Ghiringhelli
Jan 24, 2012·Gynecologic Oncology·Vijaya GalicJason D Wright
Apr 3, 2012·Seminars in Cancer Biology·Theresa L Whiteside
Aug 9, 2012·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Sreenivas AdurthiRudrapatna Subramanyam Jayshree
Sep 6, 2012·Journal of Translational Medicine·Vivian M SpaansEkaterina S Jordanova
Oct 27, 2012·British Journal of Cancer·H J M A A ZijlmansA Gorter
Nov 20, 2012·The American Journal of Pathology·Jian YeGuangyong Peng
Nov 22, 2012·Gynecologic Oncology·Maria Lina TorneselloFranco M Buonaguro
Jan 22, 2013·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal

❮ Previous
Next ❯

Citations

Dec 20, 2015·European Journal of Medical Research·Ping ZhouYongfei Wang
Apr 9, 2016·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·A Marijne HeerenEkaterina S Jordanova
Aug 25, 2016·Oral Oncology·Yu LeiGregory T Wolf
Apr 27, 2016·PloS One·Astride Audirac-ChalifourVicente Madrid-Marina
Sep 23, 2016·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Sanne SamuelsEkaterina S Jordanova
Nov 16, 2019·The Journal of Experimental Medicine·Gerardo A Vitiello, George Miller
Feb 6, 2020·International Journal of Cancer. Journal International Du Cancer·Lien LippensHannelore Denys
Aug 30, 2018·Frontiers in Immunology·Michela ColomboNatalia Platonova
Oct 1, 2016·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Sanne SamuelsEkaterina S Jordanova
May 7, 2019·Molecular Medicine Reports·Tingting LiaoYang Jin
May 22, 2020·Archives of Gynecology and Obstetrics·Masako IshikawaSatoru Kyo
Apr 1, 2020·Cellular Oncology (Dordrecht)·Nathalia FerreiraSara Granja
Mar 3, 2020·Frontiers in Immunology·Kasia A SablikMichiel G H Betjes
Dec 2, 2020·British Journal of Cancer·Tamara R LitwinNicolas Wentzensen
Mar 30, 2020·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jossie RotmanTanja D de Gruijl
Dec 18, 2020·Frontiers in Cellular and Infection Microbiology·Xue FengQiling Li
Feb 13, 2021·Annual Review of Immunology·Saikat Majumder, Mandy J McGeachy
Jun 5, 2021·Journal for Immunotherapy of Cancer·Byung-Seok KimYeonseok Chung

❮ Previous
Next ❯

Software Mentioned

ImageJ
LSM Image Browser
SPSS

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.