Foxp3 expression patterns in microscopic colitides: a clinicopathologic study of 69 patients

American Journal of Clinical Pathology
Shuting BaiNirag C Jhala

Abstract

Microscopic colitides, including lymphocytic (LC) and collagenous colitis (CC), are well-described pathologic conditions. An altered immune response is implicated in the pathogenesis of both entities. CD8+ T lymphocytes (CTLs) secrete interleukin 2 which stimulates proliferation of regulatory T cells (Tregs), and Tregs, in turn, inhibit CTLs, inducing cytotoxic tissue damage. In Tregs, Foxp3 regulates T-cell-related immune responses. The distribution of Tregs and CTLs in microscopic colitides has remained underexplored. To characterize differences in the distribution pattern of Foxp3 in biopsy specimens from patients with LC and CC, 71 colonic biopsy specimens from 69 consecutive patients were categorized into 1 of 3 diagnoses: no significant histopathologic abnormality (NSHPA), LC, or CC. Further immunohistochemical evaluation of all biopsy specimens was conducted using a panel of markers including CD8 and Foxp3. Our study demonstrated that CTL distribution pattern differences exist among these 2 colitides and that differences in the immunologic recruitment of Foxp3+ Tregs in the colonic mucosa correlate with differences in the spectrum of morphologic changes seen in patients with either LC or CC.

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Citations

Aug 2, 2012·Digestive Diseases and Sciences·Shi-Xue DaiXue-Bao Zheng
Mar 2, 2016·Journal of Crohn's & Colitis·Anna CarrascoFernando Fernández-Bañares
Nov 4, 2015·Inflammatory Bowel Diseases·Laura Francesca PisaniLuca Pastorelli
Nov 11, 2014·Histopathology·Cord LangnerUNKNOWN Working Group of Digestive Diseases of the European Society of Pathology (ESP) and the European Microscopic Colitis Group (E
Feb 26, 2016·Alimentary Pharmacology & Therapeutics·D GuagnozziA J Lucendo
Dec 16, 2020·Inflammatory Bowel Diseases·Niki DafereraAndreas Münch
Jun 12, 2021·Nature Reviews. Disease Primers·Kristin E BurkeHamed Khalili
Jul 18, 2021·Journal of Crohn's & Colitis·Yamile ZabanaAlfredo J Lucendo

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