FoxP3 in Treg cell biology: a molecular and structural perspective

Clinical and Experimental Immunology
Guoping DengMark I Greene

Abstract

Regulatory T cells (Tregs ) are specialized in immune suppression and play a dominant role in peripheral immune tolerance. Treg  cell lineage development and function maintenance is determined by the forkhead box protein 3 (FoxP3) transcriptional factor, whose activity is fine-tuned by its post-translational modifications (PTMs) and interaction partners. In this review, we summarize current studies in the crystal structures, the PTMs and interaction partners of FoxP3 protein, and discuss how these insights may provide a roadmap for new approaches to modulate Treg  suppression, and new therapies to enhance immune tolerance in autoimmune diseases.

References

Feb 12, 1993·Science·S QinH Waldmann
Dec 20, 2000·The Journal of Clinical Investigation·T A ChatilaA M Bowcock
Jan 11, 2003·Science·Shohei HoriShimon Sakaguchi
Mar 4, 2003·Nature Immunology·Jason D FontenotAlexander Y Rudensky
Jan 12, 2005·The Journal of Experimental Medicine·Casey J FoxCraig B Thompson
Mar 23, 2006·Annual Review of Immunology·Steven F Ziegler
Aug 22, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jared E LopesSteven F Ziegler
Jan 24, 2007·Nature·Alexander MarsonRichard A Young
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Bin LiMark I Greene
Mar 23, 2007·Nature·Masahiro OnoShimon Sakaguchi
Aug 21, 2007·Biochemical and Biophysical Research Communications·Joon-Young KimWilliam L Farrar
Mar 21, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jianguang DuSteven F Ziegler
Apr 22, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Samik BasuJames L Riley
Sep 10, 2008·Proceedings of the National Academy of Sciences of the United States of America·Arabinda SamantaMark I Greene
Nov 20, 2009·PloS One·Wayne W Hancock, Engin Ozkaynak
May 11, 2011·European Journal of Immunology·Rodolfo BianchiniCarlo Riccardi
Jul 30, 2011·Current Opinion in Immunology·Ulf H BeierWayne W Hancock
Nov 29, 2011·Advances in Immunology·Hyang-Mi LeeChyi-Song Hsieh
Aug 28, 2012·Nature Immunology·Dipayan RudraAlexander Y Rudensky
Nov 9, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Neelanjana ChunderAndrew D Wells
Jun 26, 2013·Nature Reviews. Cancer·Eric W-F LamChuay-Yeng Koo
Jul 16, 2013·The Journal of Biological Chemistry·Peter A MorawskiAndrew D Wells

❮ Previous
Next ❯

Citations

Nov 5, 2019·Frontiers in Immunology·Guoping DengMark I Greene
Mar 5, 2021·Frontiers in Immunology·William YipKelly M McNagny
Sep 1, 2021·Reviews in Endocrine & Metabolic Disorders·Zhongqin GongGeorge G Chen
Aug 28, 2021·Molecular Therapy : the Journal of the American Society of Gene Therapy·Viktor WixlerStephan Ludwig

❮ Previous
Next ❯

Methods Mentioned

BETA
acetylation
ubiquitination

Software Mentioned

Pymol

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Related Papers

Frontiers in Immunology
Leonn Mendes Soares PereiraAntonio Carlos Rosário Vallinoto
Journal of Clinical Immunology
Peter GeorgievTalal A Chatila
© 2021 Meta ULC. All rights reserved