FOXP3 interacts with hnRNPF to modulate pre-mRNA alternative splicing

The Journal of Biological Chemistry
Jianguang DuBaohua Zhou

Abstract

FOXP3 promotes the development and function of regulatory T cells mainly through regulating the transcription of target genes. RNA alternative splicing has been implicated in a wide range of physiological and pathophysiological processes. We report here that FOXP3 associates with heterogeneous nuclear ribonucleoprotein (hnRNP) F through the exon 2-encoded region of FOXP3 and the second quasi-RNA recognition motif (qRRM) of hnRNPF. FOXP3 represses the ability of hnRNPF to bind to its target pre-mRNA and thus modulates RNA alternative splicing. Furthermore, overexpression of mouse hnRNPF in in vitro-differentiated regulatory T cells (Tregs) reduced their suppressive function. Thus, our studies identify a novel mechanism by which FOXP3 regulates mRNA alternative splicing to modulate the function of regulatory T cells.

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Citations

Jan 8, 2021·Journal of the American Heart Association·Joshua A UhlornHeddwen L Brooks
Jun 14, 2021·Journal of Experimental & Clinical Cancer Research : CR·Zhihui DouHong Zhang
Sep 1, 2021·Reviews in Endocrine & Metabolic Disorders·Zhongqin GongGeorge G Chen
Oct 5, 2021·ACS Omega·Ankitha ShettyRiitta Lahesmaa

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