FoxP3 isoforms and PD-1 expression by T regulatory cells in multiple sclerosis

Scientific Reports
Manolo SambucciGiovanna Borsellino

Abstract

Forkhead box P3 (FoxP3)+ regulatory T cells (Treg) are powerful mediators of immune regulation and immune homeostasis. In humans, Tregs are a heterogeneous population expressing surface markers which define phenotypically and functionally distinct subsets. Moreover, it is now clear that intracellular staining for FoxP3 does not unequivocally identify "true" suppressor cells, since several FoxP3 isoforms exist, and different reagents for FoxP3 detection are available. Here, we propose a strategy to identify potentially functional and suppressive Treg cells in an autoimmune disease like multiple sclerosis, and we suggest that in patients affected by this disease these cells are both reduced in number and functionally exhausted.

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Citations

Jul 9, 2020·Clinical and Experimental Immunology·A Ahmed, A Vyakarnam
Apr 7, 2019·Nature Biomedical Engineering·Zhirui Wang, Christene A Huang
Jun 28, 2019·Therapeutic Advances in Neurological Disorders·Olaf StuveUrsula Boschert
May 17, 2019·International Journal of Molecular Sciences·Laura CorteseAlessandra Pelagalli
Apr 16, 2019·Frontiers in Endocrinology·Nishel M ShahMark R Johnson
Apr 18, 2020·Journal of Translational Medicine·Marco ChiariniUNKNOWN SURROGATE Study Group
Jan 21, 2020·Frontiers in Immunology·Manolo SambucciGiovanna Borsellino
Mar 11, 2020·Frontiers in Immunology·Rebeca Arroyo HorneroMarkus Kleinewietfeld
Jan 5, 2021·Frontiers in Immunology·Gunnar HouenJette Lautrup Frederiksen
May 18, 2020·International Immunopharmacology·Adel Mohammadzadeh
Nov 17, 2020·Frontiers in Pediatrics·Reiner K Mailer
Mar 31, 2021·Multiple Sclerosis : Clinical and Laboratory Research·Quentin Howlett-PrietoAnthony T Reder
Aug 14, 2021·Journal of Lipid Research·Luce PerieElisabetta Mueller

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Methods Mentioned

BETA
flow cytometry
Fluorescence
PCR

Software Mentioned

FlowJo

Related Concepts

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