Foxp3 Post-translational Modifications and Treg Suppressive Activity

Frontiers in Immunology
Guoping DengMark I Greene

Abstract

Regulatory T cells (Tregs) are engaged in maintaining immune homeostasis and preventing autoimmunity. Treg cells include thymic Treg cells and peripheral Treg cells, both of which can suppress the immune response via multiple distinct mechanisms. The differentiation, proliferation, suppressive function and survival of Treg cells are affected by distinct energy metabolic programs. Tissue-resident Treg cells hold unique features in comparison with the lymphoid organ Treg cells. Foxp3 transcription factor is a lineage master regulator for Treg cell development and suppressive activity. Accumulating evidence indicates that the activity of Foxp3 protein is modulated by various post-translational modifications (PTMs), including phosphorylation, O-GlcNAcylation, acetylation, ubiquitylation and methylation. These modifications affect multiple aspects of Foxp3 function. In this review, we define features of Treg cells and roles of Foxp3 in Treg biology, and summarize current research in PTMs of Foxp3 protein involved in modulating Treg function. This review also attempts to define Foxp3 dimer modifications relevant to mediating Foxp3 activity and Treg suppression. Understanding Foxp3 protein features and modulation mechanisms may help i...Continue Reading

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Citations

Mar 7, 2020·International Journal of Molecular Sciences·Malgorzata CiurkiewiczAndreas Beineke
Jul 3, 2020·Clinical Rheumatology·Matteo VecellioCarlo Selmi
Jan 21, 2020·Frontiers in Immunology·Manolo SambucciGiovanna Borsellino
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Jun 21, 2020·International Journal of Molecular Sciences·Sena KimJaebok Choi
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Nov 6, 2020·Scientific Reports·Carla AlvarezAlpdogan Kantarci
Mar 5, 2021·Frontiers in Immunology·William YipKelly M McNagny
Mar 21, 2021·Nature Reviews. Drug Discovery·Qin WuDalia Barsyte-Lovejoy
Apr 20, 2021·Frontiers in Immunology·Dorota Iwaszkiewicz-GrzesPiotr Trzonkowski
Jun 29, 2021·Frontiers in Immunology·Yujing ZhangRong Jia

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Methods Mentioned

BETA
PMA
ubiquitination
acetylation
deubiquitinase

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