FOXQ1 controls the induced differentiation of melanocytic cells.

Cell Death and Differentiation
A BagatiM A Nikiforov

Abstract

Oncogenic transcription factor FOXQ1 has been implicated in promotion of multiple transformed phenotypes in carcinoma cells. Recently, we have characterized FOXQ1 as a melanoma tumor suppressor that acts via repression of N-cadherin gene, and invasion and metastasis. Here we report that FOXQ1 induces differentiation in normal and transformed melanocytic cells at least partially via direct transcriptional activation of MITF gene, melanocytic lineage-specific regulator of differentiation. Importantly, we demonstrate that pigmentation induced in cultured melanocytic cells and in mice by activation of cAMP/CREB1 pathway depends in large part on FOXQ1. Moreover, our data reveal that FOXQ1 acts as a critical mediator of BRAFV600E-dependent regulation of MITF levels, thus providing a novel link between two major signal transduction pathways controlling MITF and differentiation in melanocytic cells.

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Citations

Dec 13, 2019·Journal of Receptor and Signal Transduction Research·Yunpeng TianHaoming Song
Dec 21, 2019·Journal of Receptor and Signal Transduction Research·Yang YangZhiyun Wang
Aug 30, 2019·Journal of Receptor and Signal Transduction Research·Long BaoZhixiong Lin
Nov 23, 2019·Journal of Receptor and Signal Transduction Research·Guanqun Ma, Yingwu Liu
Oct 30, 2019·Journal of Receptor and Signal Transduction Research·Xinyu Song, Tianchang Li
Oct 16, 2019·Journal of Cellular Physiology·Dezhi Huang, Yugang Jiang
Jan 5, 2022·Photodermatology, Photoimmunology & Photomedicine·Liang DingGyorgy Paragh

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Methods Mentioned

BETA
PCR
immunoprecipitation
ChIP
light microscopy
reverse-transcription PCR
Knockout
genotyping
transgenic

Software Mentioned

ImageQuant
GraphPad Prism

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