FOXQ1 promotes esophageal cancer proliferation and metastasis by negatively modulating CDH1

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Yangqing PeiLiang Ming

Abstract

Esophageal squamous cell carcinoma (ESCC) is an aggressive tumor with rapid progression, high recurrence and metastasis rate. Besides, the 5-year survival rate of ESCC remains dismal despite improvements in treatments having developed a lot. That is because the cellular basis of ESCC has not yet been fully understood. Forkhead box family membranes possess various kinds of properties as they mediate apoptosis, cell cycle arrest, autophagy, senescence and so on. Foxhead box Q1 (FOXQ1), which has a major impact on several kinds of tumor forming and metastasis, while whether it triggers ESCC remains largely obscure. To determine whether aberrant FOXQ1 expression in esophageal cancer, protein level and mRNA level of specimens of cancerous tissues and adjacent non-cancerous tissues were determined by western blot and real-time PCR. Then we overexpressed or knockdowned FOXQ1 in EC9706 cell; cell growth curve and colony formation were analyzed. Cell invasion ability was analyzed by migration chambers. Reporter gene assay was used to study the transcriptional regulation activity. FOXQ1 was highly expressed in esophageal cancerous tissues compared with adjacent non-cancerous tissues. FOXQ1 overexpression promotes ESCC tumor cell prolifer...Continue Reading

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Citations

Jan 23, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yong-Qiang WangHua Jiang
Mar 11, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Zhai ErtaoWu Hui
Nov 30, 2016·Nature Reviews. Urology·Hironobu YamashitaDavid J DeGraff
Jun 16, 2016·Clinical Chemistry and Laboratory Medicine : CCLM·Ting-Juan ZhangJun Qian
May 7, 2020·Cancer Metastasis Reviews·Yannasittha Jiramongkol, Eric W-F Lam
Jun 20, 2017·Molecular Medicine Reports·Pan WangLiang Ming
Oct 27, 2018·International Journal of Molecular Sciences·Duc-Hiep BachSang Kook Lee
May 14, 2016·International Journal of Oncology·Yang LiMin Xu
Apr 26, 2016·Oncology Reports·Jing ZhangYunfeng Zhang
Sep 9, 2021·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·Pihong LiMingdong Lu

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