PMID: 6414185Jan 1, 1983Paper

FPA content - a criterion of quality for plasma as factor VIII source

Vox Sanguinis
R Pflugshaupt, G Kurt

Abstract

The appearance of fibrinopeptide A (FPA) in plasma indicates that factor VIII has been at least partially activated; consequently, we asked the following questions: (1) Is the FPA content of single donor plasma influenced by the method of blood collection? (2) Does a high FPA content of the starting fresh frozen plasma impair the quality of factor VIII preparations? Using a modified procedure adapted to the assay of large series of samples, we surveyed the FPA content of normal donor plasma. Our results show that the FPA content of donor plasma depends strongly on the quality of blood collection. Improved mixing of the anticoagulant with the blood led to a drastic reduction of the FPA content of the plasma. Furthermore, two lots of factor VIII concentrates produced from FPA-poor plasma showed significant improvement in stability and solubility.

References

Aug 1, 1977·British Journal of Haematology·M E Rick, L W Hoyer
Aug 1, 1977·Thrombosis Research·V Hofmann, P W Straub
Nov 1, 1976·The Journal of Clinical Investigation·M A Shuman, P W Majerus
Jul 1, 1974·The Journal of Clinical Investigation·H L NosselG D Qureshi
Aug 1, 1980·Thrombosis Research·K BrodénH Sandberg
Jan 1, 1981·Thrombosis Research·H van HulsteijnR Bertina
May 15, 1981·Thrombosis Research·B J Woodhams, P B Kernoff

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Citations

Nov 3, 1996·Transfusion Science·U NydeggerB Lämmle
Aug 15, 1998·Vox Sanguinis·G Myllylä
Sep 9, 2006·Vox Sanguinis·P F van der Meer, R N Pietersz
Jul 19, 2012·Transfusion·Martin MacPheeGary Moroff
Nov 4, 1994·Transfusion Science·C F Högman
Feb 1, 1986·Thrombosis Research·O H SkjønsbergH C Godal
Jan 1, 1986·Vox Sanguinis·G CarlebjörkO Akerblom
Jan 1, 1986·Vox Sanguinis·O H SkjønsbergH C Godal
Jan 1, 1984·Vox Sanguinis·C V ProwseJ Gabra
Nov 4, 1994·Transfusion Science·J K Smith
Dec 10, 1989·Transfusion Science·U E NydeggerB Aeschbacher

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