FPL 62064, a topically active 5-lipoxygenase/cyclooxygenase inhibitor

Agents and Actions
A BlackhamW T Simpson

Abstract

FLP 62064 [N-(4-methoxyphenyl)-1-phenyl-1H-pyrazole-3-amine] is a dual inhibitor of prostaglandin synthetase and 5-lipoxygenase. The compound had anti-inflammatory activity in vivo in a number of models. It inhibited peritoneal inflammation induced by immune-complex when given locally. When applied to the skin, FPL 62064 inhibited UV irradiation-induced erythema and PGE2 formation in the guinea pig and also oedema formation and eicosanoid production in the mouse ear produced by arachidonic acid. Co-injected with arachidonic acid in rabbit skin, FPL 62064 inhibited oedema and eicosanoid formation.

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Citations

Sep 1, 1995·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·L H JonesJ C Freitas
Jan 30, 2002·Bioorganic & Medicinal Chemistry·Chika NakamuraToshio Satoh
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Apr 11, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kazuko YoshikawaToshihiro Hashimoto

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