FPscope: a field-portable high-resolution microscope using a cellphone lens

Biomedical Optics Express
Siyuan DongGuoan Zheng

Abstract

The large consumer market has made cellphone lens modules available at low-cost and in high-quality. In a conventional cellphone camera, the lens module is used to demagnify the scene onto the image plane of the camera, where image sensor is located. In this work, we report a 3D-printed high-resolution Fourier ptychographic microscope, termed FPscope, which uses a cellphone lens in a reverse manner. In our platform, we replace the image sensor with sample specimens, and use the cellphone lens to project the magnified image to the detector. To supersede the diffraction limit of the lens module, we use an LED array to illuminate the sample from different incident angles and synthesize the acquired images using the Fourier ptychographic algorithm. As a demonstration, we use the reported platform to acquire high-resolution images of resolution target and biological specimens, with a maximum synthetic numerical aperture (NA) of 0.5. We also show that, the depth-of-focus of the reported platform is about 0.1 mm, orders of magnitude longer than that of a conventional microscope objective with a similar NA. The reported platform may enable healthcare accesses in low-resource settings. It can also be used to demonstrate the concept of c...Continue Reading

References

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Feb 12, 2014·Optics Express·Zichao BianGuoan Zheng
Mar 26, 2014·Optics Express·Xiaoze OuChanghuei Yang
Mar 26, 2014·Optics Express·Siyuan DongGuoan Zheng
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Jun 19, 2014·Biomedical Optics Express·Siyuan DongGuoan Zheng
Sep 23, 2014·Nature Photonics·Guoan ZhengChanghuei Yang

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Citations

Aug 26, 2015·Expert Review of Medical Devices·Kaiqin ChuSebastian Wachsmann-Hogiu
Mar 18, 2015·Biomedical Optics Express·Kaikai GuoGuoan Zheng
Jul 21, 2015·Optics Express·Yongbing ZhangQionghai Dai
Apr 4, 2015·Optics Express·Liheng BianQionghai Dai
Jan 4, 2018·Journal of Biomedical Optics·Jesus Ruiz-SantaquiteriaGloria Bueno
Nov 30, 2016·Biomedical Optics Express·Jaebum ChungChanghuei Yang
Apr 1, 2020·Optics Express·Pavan Chandra KondaRoarke Horstmeyer
Dec 19, 2018·Journal of Microscopy·P PurwarJ Lee
Nov 30, 2016·Biomedical Optics Express·Liheng BianQionghai Dai
Oct 26, 2021·Advanced Biology·Mario Del RosarioRicardo Henriques

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