PMID: 11343984May 10, 2001Paper

FR167653 attenuates ischemia and reperfusion injury of the rat lung with suppressing p38 mitogen-activated protein kinase

The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
Y KawashimaY Morishita

Abstract

FR167653 is a potent suppressant of tumor necrosis factor (TNF)-alpha and interleukin-1 (IL-1) production, and was shown to attenuate ischemia and reperfusion (I/R) organ injury in our previous experiment. Because p38 mitogen-activated protein (MAP) kinase has been reported to regulate the production of TNF-alpha and IL-1, we examined the effects of FR167653 in the rat lung I/R model and determined the expression and activation of p38 MAP kinase. Experiment 1: After 1 hour of ischemia, p38 MAP kinase, phosphorylated p38 MAP kinase (active form), histologic changes of the lung, and serum levels of TNF-alpha and IL-1beta were examined. Experiment 2: After 2 hours of reperfusion, arterial oxygen content (PaO(2)) and saturation (SaO(2)), serum TNF-alpha and IL-1beta levels, and histologic changes in the lung were examined. Rats were divided into three groups in Experiment 1. In the control group, a saline solution was administered and, in the FR group, 0.1 mg/kg per hour of FR167653 was administered, intravenously throughout the experiment, beginning 30 minutes before ischemia. In the non-ischemic group, samples were taken soon after thoracotomy. The rats were divided into control and FR groups in Experiment 2. Experiment 1: One ho...Continue Reading

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Citations

Feb 24, 2006·Archives of Pharmacal Research·Yong Woo Lee, Anjali A Hirani
Feb 20, 2003·The Journal of Surgical Research·A M VaidaN M Cohen
Jan 9, 2004·American Journal of Respiratory and Critical Care Medicine·Jiangping DengRobert A Star
Apr 21, 2006·Critical Care : the Official Journal of the Critical Care Forum·Idit MatotKenneth A Jacobson
Nov 7, 2007·Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology·Masataka NishikawaHideki Yoshikawa
Nov 30, 2004·International Journal of Experimental Pathology·Hiroaki SatoNoriyuki Tanaka
Aug 18, 2004·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Alexander S FarivarMichael S Mulligan
Jul 24, 2008·Anesthesiology·Idit MatotKenneth A Jacobson
Sep 3, 2003·Nature Reviews. Drug Discovery·Sanjay KumarJohn C Lee
May 1, 2004·Stroke; a Journal of Cerebral Circulation·Toshiyuki SasakiIturo Inoue
Feb 14, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Alexander S FarivarMichael S Mulligan
Jul 22, 2017·Animal Science Journal = Nihon Chikusan Gakkaihō·Xin Jian LeiIn Ho Kim
Feb 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Makoto IshiiKazuhiro Yamaguchi
Oct 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jerry A NickG Scott Worthen

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