Fra-1 is upregulated in gastric cancer tissues and affects the PI3K/Akt and p53 signaling pathway in gastric cancer

International Journal of Oncology
Junyu HeYanhong Zhou

Abstract

Gastric cancer is an aggressive disease that continues to have a daunting impact on global health. Fra-1 (FOSL1) plays important roles in oncogenesis in various malignancies. We investigated the expression of Fra-1 in gastric cancer (GC) tissues by qPCR, immunohistochemistry (IHC) and western blot technologies. The results showed that Fra-1 was overexpressed in gastric cancer tissues compared with the adjacent non‑cancerous tissues. To explore the possible mechanism of Fra-1 in GC, we elucidated the effect of Fra-1 in the apoptosis and cell cycle of gastric cancer cells, AGS, and found that a considerable decrease in apoptotic cells and increase of S phase rate were observed for AGS cells with Fra-1 overexpession. We identified and confirmed that Fra-1 affected the expression level of CTTN and EZR in vitro through LC-MS/MS analyses and western blot technology. Furthermore, we found that Fra-1 was correlated with dysregulation PI3K/Akt and p53 signaling pathway in gastric cancer tissues in vitro. Moreover, we found that Fra-1 overexpression affected the expression of PI3K, Akt, MDM2 and p53 in vivo. In summary, our results suggest that Fra-1 is upregulated in gastric cancer tissues and plays its function by affecting the PI3K/Ak...Continue Reading

References

Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Jul 3, 2002·Nature Reviews. Cancer·Igor Vivanco, Charles L Sawyers
Sep 5, 2002·International Journal of Cancer. Journal International Du Cancer·Hanlin L WangJohn Hart
Mar 18, 2006·Cell Death and Differentiation·J E Chipuk, D R Green
Jun 21, 2006·Gene·Matthew R Young, Nancy H Colburn
Sep 27, 2008·Cell Cycle·Meng QiaoArthur B Pardee
Jul 25, 2009·Nature Reviews. Cancer·Erwin F Wagner, Angel R Nebreda
Feb 8, 2011·CA: a Cancer Journal for Clinicians·Ahmedin JemalDavid Forman
Feb 3, 2012·Cancer Biomarkers : Section a of Disease Markers·Cecilia FolioAna Patiño-García
Aug 12, 2014·Biochemical Society Transactions·Aswin G Abraham, Eric O'Neill
Sep 10, 2014·Sub-cellular Biochemistry·Qi ZhangHua Lu
Nov 12, 2014·Journal of Neuro-oncology·Shoudan Zhang, Qigui Qi
Dec 6, 2014·Cancer Research·Xuan MengYanping Zhang
Jan 1, 2015·Progress in Biophysics and Molecular Biology·Taniya SahaGaurisankar Sa
Jan 16, 2015·Journal of Carcinogenesis·Lauren Peirce Carcas
Mar 10, 2015·F1000prime Reports·Kristin K Brown, Alex Toker
Apr 4, 2015·Cancer Treatment Reviews·Franziska Briest, Patricia Grabowski
Apr 29, 2015·Frontiers in Cell and Developmental Biology·William J DavisWeimin Li
May 6, 2015·Cancer Epidemiology·Delphine PraudMarta Rossi

❮ Previous
Next ❯

Citations

Feb 28, 2019·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Jun SongRui-Xiang Zhou
Mar 21, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Di YangYiZhun Zhu
Oct 16, 2019·Molecular Biology Reports·Xiaoyan JiangSongshu Xiao
Aug 6, 2020·Scientific Reports·Christopher R NitkinVenkatesh Sampath
Jan 4, 2021·Molecular Biology Reports·Yang YangChenglin Zhou
Oct 27, 2020·Frontiers in Cell and Developmental Biology·Manying ZhangYanhong Zhou

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis