Fra-1 promotes breast cancer chemosensitivity by driving cancer stem cells from dormancy

Cancer Research
Dan LuRong Xiang

Abstract

Fra-1 is a member of the Fos transcription factor family that is highly expressed in multiple cancers, playing important roles in transformation, proliferation, and metastasis. In this study, we observed an inverse correlation between the expression of Fra-1 in human stage II breast cancer tissues and the corresponding level of clinical chemoresistance. Extending these findings in vitro, we found that knockdown of Fra-1 in breast tumor cells was sufficient to confer resistance to doxorubicin and cyclophosphamide, whereas enhanced Fra-1 expression could render these cells chemosensitive. The tumor cell side population, which is enriched for cancer stem cells, was found to be associated with chemoresistance. Increased side population fractions were detected among tumor cell lines subjected to Fra-1 knockdown. In contrast, enhanced expression of Fra-1 was correlated with a decreased side population fraction, and significantly, this finding was recapitulated in vivo, where tumors with enhanced expression of Fra-1 were found to have blunted growth. Tumor cells subjected to Fra-1 knockdown grew faster and were larger in size. Taken together, our findings suggest that Fra-1 may be an important prognostic marker for breast cancer therapy.

References

Oct 1, 1991·American Journal of Clinical Pathology·C L Hitchcock
May 1, 1988·Molecular and Cellular Biology·D R Cohen, T Curran
Jul 15, 2003·Proceedings of the National Academy of Sciences of the United States of America·Yunping LuoRong Xiang
Sep 24, 2004·Proceedings of the National Academy of Sciences of the United States of America·C Hirschmann-JaxM K Brenner
Apr 2, 2005·Nature Reviews. Cancer·Michael DeanSusan Bates
Apr 16, 2005·Molecular Cancer Research : MCR·Waldemar Debinski, Denise M Gibo
Apr 30, 2005·Proceedings of the National Academy of Sciences of the United States of America·Li XinOwen N Witte
Jun 21, 2006·Gene·Matthew R Young, Nancy H Colburn
Jun 24, 2006·The Journal of Clinical Investigation·Markus LoefflerRalph A Reisfeld
Aug 17, 2006·Blood·Jorg A KrugerRalph A Reisfeld
Oct 25, 2007·Cell Cycle·Pasquale VerdeJonathan B Weitzman
Oct 24, 2008·Nature·Kevin G LeongWei-Qiang Gao
Jan 23, 2009·Cancer Investigation·Kai MaTianyou Wang

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Citations

Dec 3, 2013·BioMed Research International·Vinitha RichardM Radhakrishna Pillai
Dec 18, 2013·Breast Cancer Research and Treatment·Yunhui HuDongsheng Xiong
Jun 14, 2013·Journal of Skin Cancer·Richard L EckertEllen A Rorke
Oct 31, 2014·Cell Death & Disease·K E McCabeD G Stupack
Jan 25, 2016·Journal of Molecular Neuroscience : MN·Yan CaoQiang Ma
Apr 23, 2013·Journal of Cellular Biochemistry·Hong-Jiang WangHai-Feng Luo
Aug 2, 2015·Experimental and Molecular Pathology·Abeer BahnassyAbdel-Rahman N Zekri
Dec 18, 2013·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Cristina MaccalliGiorgio Parmiani
May 17, 2014·Stem Cells Translational Medicine·Sarah A BlissPranela Rameshwar
Sep 29, 2017·Expert Opinion on Therapeutic Targets·David J Cantor, Gregory David
Mar 21, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Di YangYiZhun Zhu
Dec 11, 2019·International Journal of Molecular Sciences·Christiana M NeophytouPanagiotis Papageorgis
Dec 17, 2015·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Keith Syson Chan
May 14, 2014·Molecular Cancer Research : MCR·Yan ZhangXiaoyue Tan
Mar 16, 2021·The Journal of Clinical Investigation·Satoru OsukaErwin G Van Meir
Apr 6, 2021·Frontiers in Oncology·Yunus AkkocDevrim Gozuacik
Jun 30, 2021·Journal of Cancer Research and Clinical Oncology·Karen BräutigamFrank Köster

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