FRA3B and other common fragile sites: the weakest links

Nature Reviews. Cancer
Kay Huebner, Carlo M Croce

Abstract

In 1979, the first chromosome alteration associated with familial cancer was reported. Five years later, a fragile site was observed in the same chromosome region. The product of the fragile histidine triad (FHIT) gene, which encompasses this fragile site, is partially or entirely lost in most human cancers, indicating that it has a tumour-suppressor function. Inactivation of only one FHIT allele compromises this suppressor function, indicating that a 'one-hit' mechanism of tumorigenesis is operative. Are genes disrupted at other fragile sites? And, are these genes also tumour suppressors?

References

Sep 13, 1979·The New England Journal of Medicine·A J CohenR S Brown
Dec 11, 1975·Proceedings of the National Academy of Sciences of the United States of America·A G KnudsonB W Brown
Aug 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·F V RassoolM M Le Beau
Apr 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·A G Knudson
Dec 7, 1984·Science·J J Yunis, A L Soreng
May 28, 1993·International Journal of Cancer. Journal International Du Cancer·L E HanssonO Nyrén
Apr 5, 1996·Cell·G SozziC M Croce
Jun 18, 1997·Journal of the National Cancer Institute·L MaoW K Hong
Oct 6, 1997·Journal of the National Cancer Institute·I I WistubaA F Gazdar
Feb 12, 1998·Proceedings of the National Academy of Sciences of the United States of America·Z SiprashviliK Huebner
Feb 7, 1998·Proceedings of the National Academy of Sciences of the United States of America·H InoueC M Croce
Apr 1, 1998·Journal of the National Cancer Institute·G A OttersonR S Yeung
May 20, 1998·Proceedings of the National Academy of Sciences of the United States of America·H C PaceC Brenner
Jul 8, 1998·Proceedings of the National Academy of Sciences of the United States of America·D MishmarB Kerem
Jul 22, 1998·Proceedings of the National Academy of Sciences of the United States of America·Y PekarskyC M Croce
May 20, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C M CroceK Huebner
Jun 23, 1999·Proceedings of the National Academy of Sciences of the United States of America·K MimoriC M Croce
Jul 21, 1999·Proceedings of the National Academy of Sciences of the United States of America·L SardG Sozzi
Aug 14, 1999·The Journal of Biological Chemistry·A R ChaudhuriL D Barnes
Sep 25, 1999·Journal of Cellular Physiology·C BrennerK Huebner
Dec 10, 1999·International Journal of Cancer. Journal International Du Cancer·K YoshinoY Murata
Apr 12, 2000·Proceedings of the National Academy of Sciences of the United States of America·L Y FongK Huebner
Mar 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·K R DumonC M Croce
Mar 29, 2001·Molecular Therapy : the Journal of the American Society of Gene Therapy·R RameshJ A Roth
Apr 26, 2001·Proceedings of the National Academy of Sciences of the United States of America·T ShiraishiC M Croce
May 30, 2001·Trends in Genetics : TIG·R I Richards
Aug 23, 2001·Proceedings of the National Academy of Sciences of the United States of America·N ZanesiK Huebner
Sep 27, 2001·Proceedings of the National Academy of Sciences of the United States of America·A J PaigeJ E Watson
Dec 18, 2001·Genes, Chromosomes & Cancer·Martin F ArltThomas W Glover
Mar 21, 2002·Nature Reviews. Cancer·J D Rowley

❮ Previous
Next ❯

Citations

Oct 26, 2005·Human Genetics·Larissa SavelyevaManfred Schwab
Dec 27, 2005·Surgery Today·Tamotsu KurokiTakashi Kanematsu
Sep 18, 2009·Cellular and Molecular Neurobiology·Gulsah CecenerKaya Aksoy
Aug 5, 2009·Clinical Reviews in Allergy & Immunology·Wesley H Brooks
Oct 14, 2003·Biochemical Pharmacology·Nan-Shan ChangUdo Oppermann
Mar 15, 2003·Cancer Letters·Nicholas C Popescu
Mar 21, 2003·Current Biology : CB·Karlene A Cimprich
Oct 14, 2003·The Lancet Oncology·Daniel BirnbaumMax Chaffanet
May 23, 2006·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Khawla Al KurayaGuido Sauter
Feb 1, 2008·The New England Journal of Medicine·Carlo M Croce
Jul 23, 2009·Proceedings of the National Academy of Sciences of the United States of America·Alessandro RimessiRosario Rizzuto
Mar 6, 2008·The Journal of Biological Chemistry·Francesco TrapassoCarlo M Croce
Jul 20, 2006·DNA and Cell Biology·Kazuhiro IshikawaToshiyuki Saito
Dec 1, 2007·Thyroid : Official Journal of the American Thyroid Association·Eduardo P DiasLuiz De Marco
Jul 3, 2004·Genome Research·David J Mulvihill, Yuh-Hwa Wang
Mar 17, 2007·Science·Jonathan SebatMichael Wigler
Aug 17, 2005·Journal of Virology·Daniel G MillerDavid W Russell
May 16, 2003·Molecular and Cellular Biology·Nina KorsisaariTomi P Mäkelä
Feb 15, 2011·Journal of Biomedicine & Biotechnology·Alessandra DruscoNicola Zanesi
Jun 19, 2007·Cancer Research·Rami I AqeilanCarlo M Croce
Aug 10, 2006·BMC Cancer·Pascale WillemJan Schouten
Jun 28, 2013·PloS One·Megha RajaramR Scott Powers
Jun 1, 2004·International Journal of Hematology·Hideshi Ishii, Yusuke Furukawa
Dec 18, 2008·Future Oncology·Flavia PichiorriCarlo M Croce
Nov 25, 2003·Proceedings of the National Academy of Sciences of the United States of America·Ayumi MatsuyamaCarlo M Croce
Apr 9, 2004·Proceedings of the National Academy of Sciences of the United States of America·Rami I AqeilanCarlo M Croce
Mar 12, 2005·Proceedings of the National Academy of Sciences of the United States of America·Charles CoxMichael R Stratton
Dec 14, 2007·Proceedings of the National Academy of Sciences of the United States of America·Jörg WeiskeOtmar Huber
Oct 22, 2014·Proceedings of the National Academy of Sciences of the United States of America·Mohammad Abu-OdehRami I Aqeilan
Oct 7, 2014·Cellular and Molecular Life Sciences : CMLS·Catherine E WatersKay Huebner
Jul 17, 2008·Journal of Cancer Research and Clinical Oncology·Mei WangBiao Gong
Jun 1, 2008·Expert Opinion on Drug Discovery·Yutaka MidorikawaHiroyuki Aburatani
Jan 30, 2004·International Journal of Cancer. Journal International Du Cancer·Stefan Duensing, Karl Münger
Oct 21, 2003·International Journal of Cancer. Journal International Du Cancer·Christophe GinestierDaniel Birnbaum
Dec 13, 2003·Neoplasia : an International Journal for Oncology Research·Drazen B ZimonjicNicholas C Popescu
Apr 20, 2010·Pathology, Research and Practice·Halil KiyiciBeyhan Demirhan

❮ Previous
Next ❯

Related Concepts

Related Feeds

CREs: Gene & Cell Therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
Koshi MimoriCarlo M Croce
Proceedings of the National Academy of Sciences of the United States of America
Nicola ZanesiKay Huebner
Proceedings of the National Academy of Sciences of the United States of America
F V RassoolM M Le Beau
© 2022 Meta ULC. All rights reserved