Fractal analysis of mucosal microvascular patterns in oral lichen planus: a preliminary study

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Alberta LuccheseGabriel Landini

Abstract

The objective of this study was to assess local vascular architecture in atrophic-erosive oral lichen planus (OLP). We investigated the capillary structure of the oral mucosa in 31 patients with OLP and 32 healthy controls. Capillaries images were captured in vivo through a capillaroscope. We applied fractal analysis to quantify the microvasculature morphometric changes in the oral mucosa of atrophic-erosive OLP patients in terms of their fractal dimension (D). The oral vascular networks of atrophic-erosive OLP lesions had a significantly higher D, both in buccal mucosae (D=1.167, P=.019) and in tongue (D=1.196, P=.038), compared with the control population (1.123 for both locations, respectively). The present study confirms previous literature data on a close relationship between abnormal vascular architecture and atrophic-erosive OLP. Fractal analysis provided a quantitative descriptor of the complexity of the vascular patterns, which increases in the OLP samples. These data may provide new information on the OLP pathogenesis, as well as serve as morphologic quantifiers for monitoring treatment strategies.

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Citations

Feb 19, 2019·International Journal of Dermatology·Maria ContaldoAlberta Lucchese
Jul 10, 2019·International Journal of Dermatology·Maria ContaldoAlberta Lucchese
Jun 28, 2016·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Mohammed Al TarhuniDwayne N Jackson
May 10, 2017·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Enrica GentileAlberta Lucchese
Jan 30, 2021·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·R FranciottiV Perrotti

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