Fractal characteristics of human Parkinsonian neuronal spike trains

Neuroscience
G RasouliH C Kwan

Abstract

Fractal analysis was applied to human pallidal neuronal spike trains recorded from patients with Parkinson's disease during ablative surgery of the internal segment of the globus pallidus. Fractal dynamics was quantified by computing the scaling exponent with the average wavelet coefficient approach. We observed fractal persistent correlation in the fluctuation of the interspike intervals of neuronal spike trains recorded in the internal segment of the globus pallidus both before and after the administration of dopamine agonist apomorphine. However, there was a significant increase in the scaling exponent during the "on" state after apomorphine administration as compared with the parkinsonian "off" state prior to apomorphine. In addition, we observed a statistically significant decrease in the average firing rate in the transition from the "off" to the "on" state. We conclude that robust fractal dynamics can be observed in single neurons in the human CNS, indicating that human neuronal dynamics of the internal segment of the globus pallidus are essentially a nonlinear and nonequilibrium process, with a long-range correlation or memory extending across many time scales. Accompanying the "on" state after apomorphine administratio...Continue Reading

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Citations

Aug 19, 2009·Journal of Biological Physics·Mahta RasouliHon C Kwan
Apr 13, 2011·Medical Hypotheses·Avi Peled
Oct 7, 2009·Neurobiology of Disease·Cameron C McIntyre, Philip J Hahn
Sep 19, 2012·The European Journal of Neuroscience·F U HohlefeldV V Nikulin
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Nov 9, 2018·Frontiers in Human Neuroscience·Daniela Andres

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