Fractal rigidity by enhanced sympatho-vagal antagonism in heartbeat interval dynamics elicited by central application of corticotropin-releasing factor in mice

Journal of Mathematical Biology
M Meyer, O Stiedl

Abstract

The dynamics of heartbeat interval fluctuations were studied in awake unrestrained mice following intracerebroventricular application of the neuropeptide corticotropin-releasing factor (CRF). The cardiac time series derived from telemetric ECG monitoring were analyzed by non-parametric techniques of nonlinear signal processing: delay-vector variance (DVV) analysis, higher-order variability (HOV) analysis, empirical mode decomposition (EMD), multiscale embedding-space decomposition (MESD), multiexponent multifractal (MEMF) analysis. The analyses support the conjecture that cardiac dynamics of normal control mice has both deterministic and stochastic elements, is nonstationary, nonlinear, and exerts multifractal properties. Central application of CRF results in bradycardia and increased variability of the beat-to-beat fluctuations. The altered dynamical properties elicited by CRF reflect a significant loss of intrinsic structural complexity of cardiac control which is due to central neuroautonomic hyperexcitation, i.e., enhanced sympatho-vagal antagonism. The change in dynamical complexity is characterized by an effect referred to as fractal rigidity, leading to a significant impairment of adaptability to extrinsic challenges in ...Continue Reading

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Citations

Feb 6, 2010·European Journal of Pharmacology·Li-Zhen YangJoachim Spiess
Apr 9, 2008·Behavioural Brain Research·Sven Ove OgrenOliver Stiedl
Nov 22, 2007·Expert Opinion on Therapeutic Targets·Susan K Wood, James H Woods
Mar 23, 2017·IEEE Transactions on Bio-medical Engineering·Benjamin VandendriesscheFrank J Jacono
Apr 11, 2014·Critical Care Medicine·Benjamin VandendriesscheAnje Cauwels
Nov 23, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Alexander MertensMichael Meyer

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