Fractional Anisotropy of Thalamic Nuclei Is Associated With Verticality Misperception After Extra-Thalamic Stroke

Frontiers in Neurology
Taiza E G SantosDylan J Edwards

Abstract

Verticality misperception after stroke is a frequent neurological deficit that leads to postural imbalance and a higher risk of falls. The posterior thalamic nuclei are described to be involved with verticality perception, but it is unknown if extra-thalamic lesions can have the same effect via diaschisis and degeneration of thalamic nuclei. We investigated the relationship between thalamic fractional anisotropy (FA, a proxy of structural integrity), and verticality perception, in patients after stroke with diverse encephalic extra-thalamic lesions. We included 11 first time post-stroke patients with extra-thalamic primary lesions, and compared their region-based FA to a group of 25 age-matched healthy controls. For the patient sample, correlation and regression analyses evaluated the relationship between thalamic nuclei FA and error of postural vertical (PV) and haptic vertical (HV) in the roll (PVroll/HVroll) and pitch planes (PVpitch/HVpitch). Relative to controls, patients showed decreased FA of anterior, ventral anterior, ventral posterior lateral, dorsal, and pulvinar thalamic nuclei, despite the primary lesions being extra-thalamic. We found a significant correlation between HVroll, and FA in the anterior and dorsal nucl...Continue Reading

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Citations

Apr 23, 2020·Frontiers in Neurology·Zhijuan CaoGary K Steinberg
Jan 9, 2021·Stroke; a Journal of Cerebral Circulation·Zhijuan CaoGary K Steinberg
Dec 8, 2020·Annals of Physical and Rehabilitation Medicine·Camille LemaireDominic Pérennou
Sep 17, 2021·Annals of Physical and Rehabilitation Medicine·Shenhao DaiDominic Pérennou

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