Fractional calcium absorption is increased in girls with Rett syndrome

Journal of Pediatric Gastroenterology and Nutrition
K J MotilD G Glaze

Abstract

Rett syndrome (RTT), an X-linked neurodevelopmental disorder primarilyaffecting girls, is characterized in part by osteopenia and increased risk of skeletal fractures. We hypothesized that decreased intestinal calcium (Ca) absorption relative to dietary Ca intake and increased renal Ca excretion might cause these problems in RTT. We measured fractional Ca absorption, urinary Ca loss, dietary Ca intake, and the hormonal factors regulating Ca metabolism to determine whether abnormalities in Ca balance might relate to poor bone mineralization in RTT girls and to evaluate the contribution of these factors to the overall dietary Ca needs of RTT girls. Ten RTT girls and 10 controls, matched for age, sex, and pubertal status, were given a 3 day constant Ca diet that mimicked their habitual intakes. At the end of each dietary period, girls received single doses of Ca (intravenous) and Ca (oral). Fractional urinary excretion of Ca, Ca, 24 hour urinary Ca, and urinary cortisol excretion were determined. Serum Ca, phosphorous, alkaline phosphatase, vitamin D metabolites, parathyroid hormone (PTH), and osteocalcin were measured in the postabsorptive state. Bone mineral content (BMC) was measured by dual-energy x-ray absorptiometry. Fractio...Continue Reading

References

Mar 1, 1992·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S A AbramsA L Yergey
Jul 19, 1992·The New England Journal of Medicine·C C JohnstonM Peacock
May 1, 1991·Journal of Pediatric Gastroenterology and Nutrition·S A AbramsA L Yergey
May 1, 1990·Calcified Tissue International·H A MorrisB E Nordin
Nov 1, 1990·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·R P HeaneyM L Fitzsimmons
Aug 1, 1995·The Journal of Pediatrics·R D ShethJ B Bodensteiner
Aug 18, 1993·JAMA : the Journal of the American Medical Association·T LloydH E Kulin
Aug 1, 1993·The Journal of Pediatrics·S A AbramsA L Yergey
Jun 1, 1993·American Journal of Diseases of Children·R J SchultzA K Percy
Sep 11, 1995·American Journal of Medical Genetics·H LeonardJ Constantinou
Mar 1, 1997·The American Journal of Clinical Nutrition·K J EllisW W Wong
Jan 1, 1997·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·C A NowsonJ D Wark
Nov 14, 1997·The American Journal of Clinical Nutrition·S A AbramsK O O'Brien
Dec 24, 1997·The Journal of Pediatrics·R H HaasM J Hennessy
May 13, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S K AmesS A Abrams
Jun 23, 1999·Developmental Medicine and Child Neurology·H LeonardC Ellaway
Jul 10, 1999·Journal of Pediatric Gastroenterology and Nutrition·K J MotilD G Glaze
Dec 3, 1999·The American Journal of Clinical Nutrition·S A Abrams
Jan 29, 2000·The American Journal of Clinical Nutrition·B DibbaE M Poskitt
Sep 8, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·K J EllisS A Abrams
Jan 5, 2002·Calcified Tissue International·C CepollaroC Gennari
Nov 5, 2003·The American Journal of Clinical Nutrition·Geila S RozenSofia Ish-Shalom
Apr 8, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Steven A AbramsSheila K Gunn
Oct 9, 2004·The Journal of Clinical Endocrinology and Metabolism·Madhusmita MisraAnne Klibanski
Jan 11, 2005·The American Journal of Clinical Nutrition·Velimir MatkovicAlbert Clairmont
Feb 23, 2005·Nature·Florent ElefteriouGerard Karsenty

❮ Previous
Next ❯

Citations

Jul 6, 2013·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M LotanJ Merrick
Jun 4, 2011·Journal of Pediatric Gastroenterology and Nutrition·Kathleen J MotilDaniel G Glaze
Feb 15, 2012·Journal of Pediatric Gastroenterology and Nutrition·Kathleen J MotilDaniel G Glaze
Dec 24, 2010·Pediatric Research·Amanda L JeffersonHelen Leonard
Dec 24, 2010·Pediatric Research·Gitte RoendeJytte Bieber Nielsen
Jan 1, 2014·Pediatric Research·Gitte RoendeJens-Erik B Jensen
Nov 17, 2006·Proceedings of the National Academy of Sciences of the United States of America·Bryan E McGillHuda Y Zoghbi
Jul 6, 2010·Bone·Jochen G HofstaetterPaul Roschger
May 9, 2009·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·C PriorT Temudo
May 19, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Gitte RoendeJens-Erik Beck Jensen
Dec 3, 2014·Bone·Bushra KamalStuart R Cobb
Dec 7, 2007·Journal of Child Neurology·Alan K Percy
Aug 22, 2014·Journal of Pediatric Gastroenterology and Nutrition·Kathleen J MotilDaniel G Glaze
Sep 17, 2020·American Journal on Intellectual and Developmental Disabilities·Breanne J ByiersFrank J Symons
May 1, 2008·Expert Review of Endocrinology & Metabolism·Alan K Percy
Dec 17, 2018·Calcified Tissue International·Arnaud WiedemannFrançois Feillet
Sep 29, 2020·BMJ Paediatrics Open·Cary FuTimothy Benke
Jul 3, 2021·Life·Alessandra PecorelliGiuseppe Valacchi
Mar 4, 2008·Pediatrics·Jennepher DownsHelen Leonard

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.