Fractional esterification rate of HDL particles in patients with type 2 diabetes. Relation to coronary heart disease risk factors

Diabetes Care
Meng H TanJ J Frohlich

Abstract

To study the fractional esterification rate of cholesterol on HDL particles (FERHDL) in adults with type 2 diabetes and assess its correlation with serum lipids and other coronary heart disease (CHD) risk factors. FERHDL was measured in 90 adult (57 men, 33 women) patients by an isotopic assay method involving several steps, including preparation of VLDL- and LDL-depleted plasma, labeling of the sample with a trace amount of tritiated cholesterol, separation of free and esterified cholesterol fractions by chromatography post incubation, and subsequent counting of radioactivity in the individual fractions. Male patients have higher FERHDL values than their female counterparts. When HDL cholesterol was controlled for in a multivariate regression analysis, the sex factor was not significant. There was a significant positive correlation between FERHDL and plasma total cholesterol (r = 0.32), triglycerides (r = 0.82), apolipoprotein B (apo B; r = 0.48), insulin (r = 0.46), BMI (r = 0.31), and waist-to-hip ratio (WHR; r = 0.50). There was a negative correlation between FERHDL and HDL cholesterol (r = -0.76) and apolipoprotein AI (r = -0.60). When both HDL cholesterol and triglycerides were controlled for, the only significant correla...Continue Reading

Citations

Mar 26, 2003·American Journal of Physical Anthropology·Noël Cameron, Ellen W Demerath
Oct 8, 1999·Clinica Chimica Acta; International Journal of Clinical Chemistry·M Dobiásová, J J Frohlich
Jun 28, 2001·Journal of Atherosclerosis and Thrombosis·B ZhangT Ohta
Sep 13, 2016·Preventive Medicine·Meghan K Edwards, Paul D Loprinzi
Feb 4, 2003·Journal of Lipid Research·Raul D SantosRaul C Maranhão
May 1, 2004·Clinical Chemistry·Meng H TanN Bradly Glazer

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