Fractional excretion of electrolytes in volume-responsive and intrinsic acute kidney injury in dogs: Diagnostic and prognostic implications

Journal of Veterinary Internal Medicine
Roberta TroìaFrancesco Dondi

Abstract

The value of fractional excretion (FE) of electrolytes to characterize and prognosticate acute kidney injury (AKI) is poorly documented in dogs. To evaluate the diagnostic and prognostic roles of FE of electrolytes in dogs with AKI. Dogs (n = 135) with AKI treated with standard care (February 2014-December 2016). Prospective study. Clinical and laboratory variables including FE of electrolytes, were measured upon admission. Dogs were graded according to the AKI-IRIS guidelines and grouped according to AKI features (volume-responsive, VR-AKI; intrinsic, I-AKI) and outcome (survivors/non-survivors). Group comparison and regression analyses with hazard ratios (HR) evaluation for I-AKI and mortality were performed. P < .05 was considered significant. Fifty-two of 135 (39%) dogs had VR-AKI, 69/135 (51%) I-AKI and 14/135 (10%) were unclassified. I-AKI dogs had significantly higher FE of electrolytes, for example, FE of sodium (FENa, %) 2.39 (range 0.04-75.81) than VR-AKI ones 0.24 (range 0.01-2.21; P < .001). Overall, case fatality was 41% (55/135). Increased FE of electrolytes were detected in nonsurvivors, for example, FENa 1.60 (range 0.03-75.81) compared with survivors 0.60 (range 0.01-50.45; P = .004). Several risk factors for d...Continue Reading

References

Mar 1, 1997·Journal of Veterinary Internal Medicine·S L VadenE B Breitschwerdt
Oct 6, 1997·Veterinary Surgery : VS·J G HauptmanN B Olivier
Jun 8, 2007·Journal of Veterinary Internal Medicine·S BrownUNKNOWN American College of Veterinary Internal Medicine
Mar 21, 2008·Clinical Journal of the American Society of Nephrology : CJASN·Jonathan HimmelfarbJohn A Kellum
Mar 28, 2008·Veterinary Clinical Pathology·Hervé P LefebvreJean-Pierre Braun
Nov 26, 2009·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·George KosmadakisSpyridon Michail
Jan 2, 2010·Journal of the American Veterinary Medical Association·Eileen M KenneyScott P Shaw
Jan 8, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Shigehiko UchinoDonna Goldsmith
Aug 25, 2010·Journal of Veterinary Emergency and Critical Care·Maureen A LuschiniGretchen L Schoeffler
Mar 3, 2011·Nature Reviews. Nephrology·Asif A Sharfuddin, Bruce A Molitoris
Feb 10, 2012·Journal of Veterinary Emergency and Critical Care·Meredith E Thoen, Marie E Kerl
Aug 14, 2012·Journal of Veterinary Internal Medicine·E HarisonK Lamb
Sep 8, 2012·Current Opinion in Critical Care·John ProwleRinaldo Bellomo
Nov 20, 2012·Journal of Critical Care·Sean M BagshawRinaldo Bellomo
Feb 12, 2013·Critical Care : the Official Journal of the Critical Care Forum·John A KellumUNKNOWN KDIGO AKI Guideline Work Group
Aug 21, 2013·Journal of Veterinary Internal Medicine·J De LoorE Meyer
Oct 15, 2013·Critical Care : the Official Journal of the Critical Care Forum·Jill VanmassenhoveWim Van Biesen
Oct 23, 2013·The Veterinary Clinics of North America. Small Animal Practice·Barrak M Pressler
Oct 14, 2014·Case Reports in Critical Care·Daniel Vitorio, Alexandre Toledo Maciel
Dec 5, 2014·Journal of Veterinary Emergency and Critical Care·Laura B AtecaLesley G King
Jan 9, 2015·Journal of the American Society of Nephrology : JASN·John A KellumGilles Clermont
Apr 8, 2015·Journal of Veterinary Emergency and Critical Care·Iain Keir, John A Kellum
Feb 7, 2017·Nature Reviews. Nephrology·Prasad Devarajan

❮ Previous
Next ❯

Citations

Nov 11, 2019·Journal of Veterinary Internal Medicine·Erika MonariFrancesco Dondi
Jul 18, 2020·Journal of Veterinary Internal Medicine·Laura Pearl ColeKaren Humm
Jun 5, 2020·Veterinary Sciences·Eleonora GoriVeronica Marchetti
Apr 10, 2019·Critical Care : the Official Journal of the Critical Care Forum·Zhongheng ZhangYucai Hong
Nov 21, 2020·Journal of Feline Medicine and Surgery·Lauren CarvalhoCynthia Rl Webster
May 16, 2021·Journal of Veterinary Internal Medicine·Andrea CorsiniFederico Fracassi
Oct 9, 2021·Journal of Animal Physiology and Animal Nutrition·Damiano CavalliniAndrea Formigoni
Oct 27, 2021·Veterinary Clinical Pathology·Casey A DropkinDaniel K Langlois

❮ Previous
Next ❯

Methods Mentioned

BETA
urine collection

Software Mentioned

MedCalc

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Critical Care : the Official Journal of the Critical Care Forum
Sean M BagshawANZICS Database Management Committee
Clinical Journal of the American Society of Nephrology : CJASN
Isaac E HallChirag R Parikh
© 2022 Meta ULC. All rights reserved