Fractional exhaled nitric oxide concentration is increased in asbestosis and pleural plaques

Respirology : Official Journal of the Asian Pacific Society of Respirology
Alessandra SandriniDeborah H Yates

Abstract

Asbestos exposure induces generation of reactive oxygen and nitrogen species. Nitric oxide is involved in asbestos-related lung toxicity in vitro and can be measured non-invasively in humans in exhaled breath. The authors hypothesized that fractional exhaled nitric oxide concentration (FENO) would be increased in subjects with asbestos-related lung disorders. FENO was measured in 56 subjects with asbestos-related disorders (asbestosis: 12; pleural plaques: 32; asbestos-related diffuse pleural thickening: 12) and in 35 normal subjects. The authors also measured exhaled carbon monoxide, another marker of lung inflammation. Median (25-75 percentile) FENO was increased in subjects with asbestosis (7.9 (6.6-15.7) p.p.b.; P=0.001) and pleural plaques (6.3 (5.3-9) p.p.b.; P=0.03) compared with normal controls (4.6 (3.5-6) p.p.b.). Subjects with DPT had a median FENO of 5.6 p.p.b., similar to controls. No significant differences in exhaled carbon monoxide were observed between controls (1.0+/-0.3 p.p.m.) and subjects with asbestosis (1.3+/-0.3 p.p.m.), pleural plaques (1.2+/-0.3 p.p.m.) or diffuse pleural thickening (1.1+/-0.3 p.p.m.). FENO is raised in asbestosis consistent with lung inflammation, and also in pleural plaques.

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Citations

Feb 15, 2007·Respirology : Official Journal of the Asian Pacific Society of Respirology·Philip J Thompson, Fan Chung
Jun 28, 2008·American Journal of Respiratory and Critical Care Medicine·Eun-Kee ParkAnthony R Johnson
Jan 1, 2013·Italian Journal of Pediatrics·Angelo MannaFrancesca Santamaria
Nov 3, 2009·Annals of Thoracic Medicine·Abdullah A Abba
Oct 16, 2010·Advanced Powder Technology : the International Journal of the Society of Powder Technology, Japan·Alquam Mashir, Raed A Dweik
Dec 17, 2014·Occupational and Environmental Medicine·Leonid KopylevGlinda S Cooper
Oct 24, 2013·BioMed Research International·Attapon Cheepsattayakorn, Ruangrong Cheepsattayakorn
Feb 19, 2010·Respiratory Medicine·Lauri LehtimäkiEeva Moilanen
Dec 19, 2014·Inhalation Toxicology·Laura E KerperJulie E Goodman
Jun 13, 2009·Respiratory Medicine·Sharron ChowDeborah H Yates
Jan 2, 2015·Allergy, Asthma & Immunology Research·Woo-Jung SongSoo-Jong Hong
Mar 9, 2011·Journal of Breath Research·Eleanor A ChapmanDeborah H Yates
Feb 14, 2020·International Journal of Environmental Research and Public Health·Zehra Nur TöreyinLode Godderis
Aug 17, 2019·Royal Society Open Science·Philip I BucklandEva Panagiotakopulu
Jan 12, 2012·Journal of Breath Research·Sharron ChowDeborah H Yates
Jan 13, 2019·Respiratory Research·Conal HaytonStephen J Fowler
Sep 2, 2020·International Journal of Molecular Sciences·Paolo CameliRosa Metella Refini
Apr 8, 2014·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Kevin LamoteJan P van Meerbeeck
Mar 5, 2021·Respiratory Medicine·Ourania S KotsiouSotirios G Zarogiannis

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