Fractional exhaled nitric oxide (FeNO) may predict exercise-induced bronchoconstriction (EIB) in schoolchildren with atopic asthma

Nitric Oxide : Biology and Chemistry
Tomasz GrzelewskiIwona Stelmach

Abstract

There is a need for the performance of exercise-induced bronchoconstriction (EIB) tests in the monitoring of childhood asthma control. We aimed to evaluate whether in children with atopic asthma, EIB can be predicted by one or more of the following parameters or by their combination: fractional exhaled nitric-oxide (FeNO), allergy profile, asthma treatment, total IgE serum concentration and eosinophil blood count (EBC). It was a retrospective, cross-sectional study. We evaluated data from medical documentation of children with atopic asthma who had performed standardized spirometric exercise challenge test. One hundred and twenty six patients with atopic asthma, aged 5-18, were included in the analysis. There were two groups of patients: the EIB group (n=54) and the no-EIB group (n=72). The median FeNO level prior to exercise in the EIB group was 27.6 vs. 16.3 ppb in the no-EIB group (p=0.002). FeNO level higher than 16 ppb had the highest diagnostic value to confirm EIB. When using the FeNO level of >16 ppb, the sensitivity, specificity, negative predictive and positive predictive values for EIB were 83%, 46.9%, 74.2%, and 60%, respectively. In the EIB group, the degree of FeNO elevation did correlate positively with the absol...Continue Reading

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Citations

Jan 1, 2013·Italian Journal of Pediatrics·Angelo MannaFrancesca Santamaria
Oct 27, 2015·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Aline F BritoBagnólia A Silva
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Dec 13, 2017·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Tugba ArıkogluSemanur Kuyucu
May 18, 2019·BMC Pulmonary Medicine·Melanie DreßlerJohannes Schulze

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