Fractional flow reserve versus angiography for guidance of PCI in patients with multivessel coronary artery disease (FAME): 5-year follow-up of a randomised controlled trial

Lancet
Lokien X van NunenFAME Study Investigators

Abstract

In the Fractional Flow Reserve Versus Angiography for Multivessel Evaluation (FAME) study, fractional flow reserve (FFR)-guided percutaneous coronary intervention (PCI) improved outcome compared with angiography-guided PCI for up to 2 years of follow-up. The aim in this study was to investigate whether the favourable clinical outcome with the FFR-guided PCI in the FAME study persisted over a 5-year follow-up. The FAME study was a multicentre trial done in Belgium, Denmark, Germany, the Netherlands, Sweden, the UK, and the USA. Patients (aged ≥ 18 years) with multivessel coronary artery disease were randomly assigned to undergo angiography-guided PCI or FFR-guided PCI. Before randomisation, stenoses requiring PCI were identified on the angiogram. Patients allocated to angiography-guided PCI had revascularisation of all identified stenoses. Patients allocated to FFR-guided PCI had FFR measurements of all stenotic arteries and PCI was done only if FFR was 0·80 or less. No one was masked to treatment assignment. The primary endpoint was major adverse cardiac events at 1 year, and the data for the 5-year follow-up are reported here. Analysis was by intention to treat. This trial is registered with ClinicalTrials.gov, number NCT00267...Continue Reading

Associated Clinical Trials

References

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Aug 29, 2012·The New England Journal of Medicine·Bernard De BruyneUNKNOWN FAME 2 Trial Investigators
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Citations

Feb 19, 2016·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Nikant Sabharwal, Avijit Lahiri
Feb 13, 2016·Journal of Interventional Cardiology·Cindy L GrinesTheodore L Schreiber
Jan 5, 2016·European Heart Journal·Philippe Gabriel StegWilliam Wijns
Dec 30, 2015·Chinese Medical Journal·Guo-Xin FanJi-Kun Wang
Oct 2, 2015·Cardiology and Therapy·Islam Y ElgendyAnthony A Bavry
Sep 4, 2015·Lancet·Steven P Sedlis, Jeffrey D Lorin
Apr 5, 2016·Expert Review of Cardiovascular Therapy·Michael O Kayatta, Michael E Halkos
Feb 4, 2016·Expert Review of Cardiovascular Therapy·Sara C Martinez, David R Holmes
Jun 16, 2016·Lancet·Aaron DaleUNKNOWN COMPare project team
Jun 11, 2016·Journal of the American College of Cardiology·Nils P JohnsonViviany R Taqueti
Jun 13, 2016·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Javier EscanedPatrick W Serruys
Jul 28, 2016·Trends in Cardiovascular Medicine·Jae Yoon ParkJoerg Herrmann
Jul 20, 2016·Circulation Journal : Official Journal of the Japanese Circulation Society·Nico Hj Pijls, Bernard De Bruyne
Aug 9, 2016·Trends in Cardiovascular Medicine·Emanuele Barbato
Jul 30, 2016·Journal of Cardiovascular Medicine·Hemang B PanchalTimir K Paul
Aug 16, 2016·Cardiovascular Drugs and Therapy·Jason M Tarkin, Juan Carlos Kaski
May 3, 2016·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Doyeon HwangBon-Kwon Koo
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Jan 15, 2017·Cardiovascular Diabetology·Giuseppe GargiuloUNKNOWN CONTRST Study Investigators
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