Fractionated 5-aminolaevulinic acid-photodynamic therapy vs. surgical excision in the treatment of nodular basal cell carcinoma: results of a randomized controlled trial

The British Journal of Dermatology
Klara MosterdD I M Kuijpers

Abstract

Skin cancer incidence rates have been increasing for decades and this increase is expected to continue. Surgical excision (SE) is the treatment of first choice for nodular basal cell carcinoma (nBCC). Photodynamic therapy (PDT) has proven to be an effective treatment for superficial basal cell carcinoma. Its long-term efficacy in nBCC has not yet been established. Prospectively compare the efficacy of 5-aminolaevulinic acid (ALA)-PDT and SE in terms of failure rates with long-term follow-up. Determinants of failure in the study population, such as the effect of tumour depth, were analysed retrospectively. A randomized controlled trial in 173 primary nBCCs in 149 patients. Primary nBCCs were randomly assigned either to PDT (n = 85) or to SE (n = 88). Tumours treated with PDT were illuminated twice on the same day, 4 h after application of ALA cream, 3 weeks after debulking. SE was performed under local anaesthesia with a 3-mm margin, followed by histological examination. An intention-to-treat analysis was performed. In total, 171 primary nBCCs in 149 patients were treated. A 3-year interim analysis revealed that the cumulative incidence of failure was 2.3% for SE and 30.3% for PDT (P < 0.001). Tumour depth and other analysed det...Continue Reading

References

Jan 1, 1997·British Journal of Cancer·M F AvrilD Chassagne
Dec 21, 2000·The British Journal of Dermatology·S A HolmeD L Roberts
Sep 22, 2001·Journal of Photochemistry and Photobiology. B, Biology·Q PengK E Giercksky
Feb 14, 2002·The Journal of Investigative Dermatology·Monique R ThissenH A Martino Neumann
Sep 18, 2004·The Journal of Investigative Dermatology·Esther de VriesJan Willem Coebergh
Mar 25, 2005·The British Journal of Dermatology·E de VriesJ W W Coebergh
Dec 24, 2005·The Journal of Investigative Dermatology·Even Angell-PetersenKarl-Erik Giercksky
May 10, 2006·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Philip R CohenBruce R Nelson
Dec 28, 2006·Journal of the American Academy of Dermatology·Lasse R BraathenUNKNOWN International Society for Photodynamic Therapy in Dermatology
Mar 14, 2007·Journal of Photochemistry and Photobiology. B, Biology·Miron KaliszewskiJohan Moan
Apr 25, 2007·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Danielle I M KuijpersMartino H A M Neumann
Nov 23, 2007·Journal of the European Academy of Dermatology and Venereology : JEADV·E R M de HaasD J Robinson

❮ Previous
Next ❯

Citations

Nov 28, 2013·Plastic and Reconstructive Surgery·Matthew L IorioSteven P Davison
Oct 15, 2013·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Kate RossNeil Fenske
Apr 16, 2014·American Journal of Clinical Dermatology·Charlotte M ClarkJulian M Mackay-Wiggan
Oct 2, 2015·International Journal of Molecular Sciences·Paola SavoiaPaolo Broganelli
Jun 27, 2012·Expert Opinion on Drug Delivery·Nina Dragicevic-Curic, Alfred Fahr
Nov 29, 2011·Dermatologic Clinics·Randie H Kim, April W Armstrong
May 5, 2011·Seminars in Cutaneous Medicine and Surgery·Lori BrightmanRoy Geronemus
Mar 17, 2010·Photodiagnosis and Photodynamic Therapy·Sally H Ibbotson
Jul 14, 2009·Journal of Photochemistry and Photobiology. B, Biology·Tim Smits, Anne C E Moor
Nov 9, 2010·Journal of the European Academy of Dermatology and Venereology : JEADV·F FantiniP G Calzavara-Pinton
Jul 5, 2012·Journal of the European Academy of Dermatology and Venereology : JEADV·E A W WolberinkM J P Gerritsen
Aug 2, 2012·Lasers in Surgery and Medicine·Christian S BetzColin Hopper
Nov 28, 2012·Journal of the European Academy of Dermatology and Venereology : JEADV·C A MortonL R Braathen
May 28, 2011·CA: a Cancer Journal for Clinicians·Patrizia AgostinisJakub Golab
Oct 10, 2015·Future Oncology·Tiago Ribeiro Correia de SáJosé Manuel Lopes
Mar 16, 2013·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Anthony J DixonJohn B Dixon
Jul 2, 2016·Journal of Cosmetic Dermatology·Yurui ZouHui Lin
Oct 25, 2016·Methods : a Companion to Methods in Enzymology·Pablo Fonda-PascualPedro Jaen-Olasolo
Oct 27, 2016·Cancers·Liezel L Griffin, John T Lear
May 20, 2015·Journal of Cutaneous Medicine and Surgery·David ZlotyUNKNOWN Canadian Non-melanoma Skin Cancer Guidelines Committee
Jul 26, 2018·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Donald E NealJeremy R Etzkorn
Feb 12, 2019·Current Treatment Options in Oncology·Keiji Tanese
May 21, 2011·International Journal of Dermatology·Laura A Kwasniak, Jorge Garcia-Zuazaga
Sep 16, 2020·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·Lukas KoflerHelmut Breuninger
May 14, 2020·International Journal of Molecular Sciences·Daniela LeónPriscilla Brebi
Nov 18, 2020·The Cochrane Database of Systematic Reviews·Jason ThomsonFiona J Bath-Hextall
Nov 22, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Nicholas J Collier, Lesley E Rhodes
Sep 24, 2019·Clinical Oncology : a Journal of the Royal College of Radiologists·N O'DonoghueA J Sykes
Jan 16, 2021·The British Journal of Dermatology·J ThomsonF J Bath-Hextall
May 30, 2021·The British Journal of Dermatology·I NasrUNKNOWN British Association of Dermatologists’ Clinical Standards Unit
Apr 4, 2020·Actas dermo-sifiliográficas·F Vílchez-MárquezP Redondo-Bellón

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Basal Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.