PMID: 2165739Aug 1, 1990

Fractionated proton radiation therapy of cranial and intracranial tumors

American Journal of Clinical Oncology
M Austin-SeymourC Crowell


Since 1973 fractionated proton radiation therapy has been used in the treatment of malignant disease. Protons have favorable physical characteristics that yield dose distributions superior to those of photons in certain clinical situations. As of December 31, 1987, 1,678 patients had been treated. Of these, 110 had chordomas or low-grade chondrosarcomas of the base of skull. The first 68 patients have a minimum follow-up of 17 months. The median dose was 69 Cobalt Gray Equivalent (CGE). (CGE is the dose in proton Gray multiplied by 1.1, which is the relative biological effectiveness for protons relative to 60Cobalt.) The actuarial 5-year local control rate is 82%, and the disease-free survival rate is 76%. Thirteen patients with meningiomas have been treated, following subtotal resection. The median dose was 59.4 CGE. With a median follow-up of 26 months, no patient has had tumor progression. In addition, nine patients with gliomas and 12 with craniopharyngiomas have been treated.


Jan 1, 1994·Journal of Neuro-oncology·R Desai, J Bruce
Mar 1, 1995·Radiation and Environmental Biophysics·J-L HabrandJ M Cosset
Aug 3, 2005·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·John A Kalapurakal
Dec 1, 1995·International Journal of Radiation Oncology, Biology, Physics·S J RosenthalA F Thornton
Jul 15, 1996·International Journal of Radiation Oncology, Biology, Physics·P L Petti
Jun 12, 2013·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Anjuli LittleTaufik A Valiante
May 1, 1999·Urology·James M SlaterJerry D Slater
Jun 6, 2000·International Journal of Radiation Oncology, Biology, Physics·J DebusM Wannenmacher
Sep 1, 1996·International Journal of Radiation Oncology, Biology, Physics·M Goitein, A Niemierko
Jun 2, 1998·International Journal of Radiation Oncology, Biology, Physics·N MuthukumarJ C Flickinger
Mar 12, 2008·Skull Base : Official Journal of North American Skull Base Society ... [et Al.]·Masashi TamakiKikuo Ohno
Jul 17, 1998·Journal of Neurology, Neurosurgery, and Psychiatry·A G KortenA M Van de Wel
Jul 5, 2007·Neurosurgical Focus·Jay JagannathanLawrence S Chin
Oct 29, 2013·Journal of Neurosurgery·Roberto Jose DiazMichael D Cusimano
May 6, 2014·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·B KayaniT W R Briggs
May 1, 1992·European Journal of Pediatrics·K OexleE N Probst
Dec 8, 2005·Acta Oncologica·Erik BlomquistBengt Glimelius
Dec 8, 2005·Acta Oncologica·Thomas Björk-ErikssonBengt Glimelius
Feb 4, 2012·The Lancet Oncology·Brian P WalcottManuel J Ferreira
Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·James M SlaterJerry D Slater
Mar 2, 2010·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Stephanie E CombsDaniela Schulz-Ertner
Jul 1, 1994·International Journal of Radiation Oncology, Biology, Physics·J R CastroT L Phillips
Dec 11, 2007·International Journal of Radiation Oncology, Biology, Physics·Hans Peter RutzBeate Timmermann
Feb 1, 2008·Surgical Neurology·Nasrin FatemiDaniel F Kelly
May 15, 2007·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Dag Rune OlsenInger Natvig Norderhaug
Jun 24, 2006·Neurosurgery Clinics of North America·John H Suh, Nalin Gupta
Nov 7, 2006·International Journal of Radiation Oncology, Biology, Physics·Hans Peter RutzGudrun Goitein
Nov 9, 2006·Advances in Pediatrics·Joshua A MayMitchell E Geffner
Jun 28, 2005·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·G NoëlJ-J Mazeron
Jul 10, 2012·International Journal of Radiation Oncology, Biology, Physics·Jerry D SlaterJames M Slater
Nov 1, 1993·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·G GademannM Wannenmacher
Mar 9, 2011·Journal of Neuro-oncology·Roberto Jose Diaz, Michael D Cusimano
Feb 19, 2015·Current Opinion in Otolaryngology & Head and Neck Surgery·Raewyn G CampbellRicardo L Carrau
Jun 1, 1997·Postgraduate Medical Journal·N S BridS R Yadav
Nov 27, 2018·Neurosurgery·Jennifer VogelRobert A Lustig
Jan 1, 1993·British Journal of Neurosurgery·L WatkinsH A Crockard

Related Concepts

Brain Tumor, Recurrent
Papillary Craniopharyngioma
Mixed Gliomas
Spinal Meningioma
Radiotherapy Dosage
Radiotherapy, Computer-Assisted
Skull Neoplasms

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