Fractionated stereotactic conformal radiotherapy for secreting and nonsecreting pituitary adenomas

Clinical Endocrinology
G MinnitiM Brada

Abstract

To assess the medium-term outcome in a cohort of patients with residual or recurrent pituitary adenoma treated with fractionated stereotactic conformal radiotherapy (SCRT). Ninety-two patients (median age 50 years) with a residual or recurrent nonfunctioning (67) or a secreting (25) pituitary adenoma were treated between 1995 and 2003. Eighteen patients had a GH-secreting, five PRL-secreting and two an ACTH-secreting pituitary adenoma. Vision was impaired in 39 patients, with visual field deficit (35) and/or reduced visual acuity (25). Sixty-four patients had partial or complete hypopituitarism before SCRT. The treatment was delivered stereotactically by four noncoplanar conformal fixed fields using a 6-MV linear accelerator to a dose of 45 Gy in 25 fractions. At a median follow-up of 32 months (range 4-108) the 1, 3 and 5 years actuarial progression-free survival is 99%, 98% and 98%, and overall survival is 98%. Three patients recurred 5 months, 1 year and 9 years after SCRT requiring surgery. In secreting adenomas, hormone levels declined progressively, becoming normal in more than a third of patients with GH-secreting and PRL-secreting pituitary tumours. 50% of baseline GH level was achieved in just under 2 years. The treatm...Continue Reading

References

Aug 11, 1991·International Journal of Radiation Oncology, Biology, Physics·W M McColloughR R Million
Oct 1, 1990·Journal of Neurosurgery·O al-MeftyR R Smith
Jun 1, 1989·International Journal of Radiation Oncology, Biology, Physics·P W GrigsbyH G Schwartz
Aug 1, 1985·Ophthalmology·L B KlineR Ceballos
Sep 30, 1995·International Journal of Radiation Oncology, Biology, Physics·D ZierhutM Wannenmacher
Oct 15, 1994·International Journal of Radiation Oncology, Biology, Physics·R W TsangW J Simpson
Nov 15, 1994·International Journal of Radiation Oncology, Biology, Physics·I SyndikusL Jannoun
Jun 1, 1993·Radiology·B J FisherB Noone
Mar 15, 1997·International Journal of Radiation Oncology, Biology, Physics·S Rush, P R Cooper
Oct 6, 1997·International Journal of Radiation Oncology, Biology, Physics·M W McCordW A Friedman
May 14, 1998·Clinical Endocrinology·N J GittoesP M Stewart
Dec 2, 1998·Journal of Neurosurgery·P BreenA J Martinez
Dec 17, 1998·Journal of Neurology, Neurosurgery, and Psychiatry·E M GuinanM D Kopelman
Jul 13, 2000·International Journal of Radiation Oncology, Biology, Physics·R SasakiY Kuroda
Jan 13, 2001·Clinical Endocrinology·A C WoollonsV Balakrishnan
May 29, 2001·European Journal of Endocrinology·K Boelaert, N J Gittoes
Nov 27, 2001·European Journal of Endocrinology·R CozziR Attanasio
Dec 4, 2002·Clinical Endocrinology·M BradaB Rajan
Sep 16, 2003·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Alfons C M van den BerghJan Willem R Pott
Jul 6, 2004·International Journal of Radiation Oncology, Biology, Physics·Stefanie Milker-ZabelJürgen Debus
Nov 4, 2004·Clinical Endocrinology·M BradaG Minniti
Jan 27, 2005·Clinical Endocrinology·Giuseppe MinnitiRiccardo Maurizi Enrici
Feb 15, 2005·International Journal of Radiation Oncology, Biology, Physics·Sun Ha PaekDavid W Andrews
May 14, 2005·International Journal of Radiation Oncology, Biology, Physics·Philippe ColinPascal Rousseaux
Jul 20, 2005·Treatments in Endocrinology·Thankama Ajithkumar, Michael Brada

❮ Previous
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Citations

Mar 31, 2010·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Mario Francesco FraioliLaura Moschettoni
Feb 14, 2008·Pituitary·Ken H Darzy, Stephen M Shalet
Feb 21, 2008·Pituitary·Andrew A KannerYona Greenman
Sep 13, 2008·Reviews in Endocrine & Metabolic Disorders·G MinnitiM Brada
Jan 30, 2008·Nature Clinical Practice. Neurology·Lisa B Nachtigall, Helen A Shih
Oct 16, 2009·Radiation Oncology·Giuseppe MinnitiRiccardo Maurizi Enrici
Dec 6, 2011·Radiation Oncology·Giuseppe MinnitiRiccardo Maurizi Enrici
Apr 14, 2011·Radiation Oncology·Giuseppe MinnitiRiccardo Maurizi Enrici
May 2, 2008·Neurosurgical Focus·Samer GhostineWalter D Johnson
Feb 6, 2010·European Journal of Endocrinology·S RougU Feldt-Rasmussen
Feb 18, 2014·Journal of Neuro-oncology·Arnar AstradssonMarianne Juhler
Jun 23, 2016·Reports of Practical Oncology and Radiotherapy : Journal of Greatpoland Cancer Center in Poznań and Polish Society of Radiation Oncology·Giuseppe MinnitiRiccardo Maurizi Enrici
Aug 6, 2014·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Jan Patrick BoströmKlaus Hamm
Jan 4, 2013·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·M KocherR-P Mueller
Sep 10, 2013·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·C KoppA-L Grosu
Oct 23, 2015·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Hiren PattNalini S Shah
Mar 12, 2013·Seminars in Radiation Oncology·Stephanie E CombsMichael Brada
Oct 9, 2012·Neurosurgery Clinics of North America·Jason P SheehanMark J Lobo
Aug 9, 2011·Otolaryngologic Clinics of North America·Paul LeeJerry R Greenfield
Feb 9, 2011·World Neurosurgery·Shota TanakaBruce E Pollock
Mar 17, 2010·Endocrinología y nutrición : órgano de la Sociedad Española de Endocrinología y Nutrición·Carmen Alameda HernandoCésar Varela Da Costa
Jul 25, 2009·Endocrinología y nutrición : órgano de la Sociedad Española de Endocrinología y Nutrición·Cristina Lamas Oliveira, Javier Estrada García
Jun 16, 2009·European Journal of Internal Medicine·Marleen KarsJohannes A Romijn
Jan 30, 2008·Endocrinology and Metabolism Clinics of North America·Michael Brada, Petra Jankowska
Nov 22, 2007·International Journal of Radiation Oncology, Biology, Physics·Bruce E PollockPaula J Schomberg
Dec 13, 2006·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Giuseppe MinnitiMichael Brada
Mar 1, 2012·Clinical Endocrinology·B C WhitelawS J B Aylwin
Apr 24, 2012·Annales d'endocrinologie·Philippe Chanson, Peter Kamenický
Sep 27, 2013·British Journal of Neurosurgery·Sauradeep SarkarAri George Chacko
Jun 28, 2015·Annales d'endocrinologie·Christine Cortet-RudelliPhilippe Chanson
May 3, 2011·International Journal of Radiation Oncology, Biology, Physics·Christine KoppAnca-Ligia Grosu
Mar 4, 2015·Endocrinology and Metabolism Clinics of North America·Georgia Ntali, Niki Karavitaki
Apr 21, 2012·International Journal of Endocrinology·G MinnitiR Maurizi Enrici
Oct 13, 2016·Radiation Oncology·Giuseppe MinnitiMaximillian Niyazi
May 29, 2014·Neurosurgery·Cheng-Chia LeeJason P Sheehan

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