Fractionated stereotactic radiotherapy of optic pathway gliomas: tolerance and long-term outcome

International Journal of Radiation Oncology, Biology, Physics
Stephanie E CombsJürgen Debus

Abstract

To evaluate the effectiveness and toxicity of fractionated stereotactically guided radiotherapy (FSRT) in the management of optic glioma. Fifteen patients with optic pathway gliomas were treated with FSRT at our institution between 1990 and 2003. A median target dose of 52.2 Gy (range, 45.2-57.6 Gy) was applied using a median fractionation of 5 fractions of 1.8 Gy weekly using a linear accelerator. The median follow-up time was 97 months (range, 8-151 months). Of the 15 patients, 1 died of tumor progression during the follow-up period. The progression-free survival rate at 3 and 5 years was 92% and 72%, respectively. The median overall survival after FSRT was 90 months (range, 8-151 months). The 5-year survival rate after FSRT was 90%. We did not observe secondary malignancies. Fractionated stereotactic radiotherapy was safe and well tolerated in all patients. The good tumor control and the potential of sparing normal brain tissue, especially the pituitary gland in lesions involving the optic chiasm, permit effective treatment of patients with optic nerve gliomas. Longer follow-up is needed to assess the incidence of late effects fully.

References

Jan 1, 1978·Journal of Neurosurgery·D C Oxenhandler, M P Sayers
Oct 1, 1991·European Journal of Pediatrics·A M Lund, F Skovby
Aug 1, 1991·International Journal of Radiation Oncology, Biology, Physics·J P BatainiD Ponvert
Jun 1, 1990·The Journal of Pediatrics·R Listernick, J Charrow
Feb 1, 1990·Neurosurgery·L A RodriguezV A Levin
Apr 1, 1990·International Journal of Radiation Oncology, Biology, Physics·J J KovalicP R Thomas
Mar 1, 1987·Cancer·L WeissR L Dubowy
Dec 1, 1989·The British Journal of Ophthalmology·J E WrightW I McDonald
Jun 1, 1985·International Journal of Radiation Oncology, Biology, Physics·A Horwich, H J Bloom
Jan 1, 1980·International Journal of Radiation Oncology, Biology, Physics·B F DanoffN Thompson
May 1, 1983·International Journal of Radiation Oncology, Biology, Physics·J T ParsonsR R Million
Aug 1, 1984·Ophthalmology·R A LewisR P Whitford
Oct 1, 1982·Journal of Neurosurgery·R T TennyJ A Rush
Aug 1, 1980·The British Journal of Ophthalmology·J E WrightN B Call
Jul 30, 1994·International Journal of Radiation Oncology, Biology, Physics·M MenkeW Schlegel
Nov 1, 1993·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·G GademannM Wannenmacher
Jan 15, 1993·International Journal of Radiation Oncology, Biology, Physics·D JenkinB Hendrick
Apr 1, 1997·Brain Pathology·E AlshailH J Hoffman
Apr 12, 2000·International Journal of Radiation Oncology, Biology, Physics·A TrottiW Curran
Apr 13, 2000·International Journal of Radiation Oncology, Biology, Physics·J DebusM Wannenmacher
Jul 18, 2000·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·G G GrabenbauerR Sauer
May 15, 2002·International Journal of Radiation Oncology, Biology, Physics·Frank H SaranMichael Brada
Jun 29, 2002·Archives of Disease in Childhood·S SinghalD G R Evans
Jun 6, 2003·International Journal of Radiation Oncology, Biology, Physics·Yasser KhafagaDerek Jenkin
Jul 17, 2003·British Journal of Cancer·T G ClarkD G Altman
Jul 31, 2003·British Journal of Cancer·M J BradburnD G Altman
Sep 1, 1957·Journal of Neurosurgery·F D FOWLER, D D MATSON
Nov 1, 1961·The British Journal of Surgery·R TYM
Nov 25, 2003·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Rolf-Dieter KortmannMichael Bamberg
Nov 25, 2003·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Mart HeestersGwan K Go

❮ Previous
Next ❯

Citations

Jan 23, 2013·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Seong Rok HanChae Heuck Lee
Jan 9, 2013·Neuro-oncology·Amy Lee ChongUte Bartels
Aug 26, 2006·Current Opinion in Ophthalmology·Grant T Liu
Jul 13, 2013·Current Opinion in Ophthalmology·Nandini G Gandhi
Aug 23, 2011·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Robert A AveryGrant T Liu
Oct 21, 2009·Journal of Child Neurology·Angela J Sievert, Michael J Fisher
Oct 26, 2006·Neurologia Medico-chirurgica·Junichi MiyamotoKatsuyoshi Mineura
Mar 19, 2013·Journal of Neurosurgery. Pediatrics·Nuri UsluYildiz Guney
Nov 17, 2007·Neurosurgical Focus·Andrew G Lee
Nov 17, 2007·Neurosurgical Focus·Mandy J BinningMarion L Walker
Dec 15, 2010·Neurology India·Kalyan BommakantiA K Purohit
Nov 10, 2011·Journal of Pediatric Neurosciences·C E DeopujariN J Shah
Dec 11, 2013·Medical Physics·Alexander SchlaeferChristoph Fürweger
Apr 17, 2014·International Ophthalmology·Akshay Gopinathan NairRashmin A Gandhi
Jan 4, 2013·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·M KocherR-P Mueller
Nov 11, 2011·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·J ShapeyA H Kaye
Jun 1, 2010·International Journal of Radiation Oncology, Biology, Physics·Rudolf KorinthenbergGuido Nikkhah
Aug 9, 2008·International Journal of Radiation Oncology, Biology, Physics·Stacy WentworthEdward G Shaw
Nov 10, 2015·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·A LaprieUNKNOWN radiotherapy committee of SFCE and France Hadron
Aug 19, 2015·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Kristian AquilinaFrederick A Boop
Jan 17, 2009·Pediatric Blood & Cancer·Valérie de HaasChantal Kalifa
Mar 28, 2007·Annals of Neurology·Robert ListernickDavid H Gutmann
Jan 27, 2015·Current Treatment Options in Neurology·Reena P ThomasLawrence Recht
Nov 21, 2007·Expert Review of Anticancer Therapy·Luca MassimiConcezio Di Rocco
Jan 22, 2009·Current Opinion in Neurology·Helmut Wilhelm
Jan 18, 2006·Pediatric Blood & Cancer·Christopher D Jahraus, Nancy J Tarbell
Jan 27, 2006·Current Opinion in Ophthalmology·Christin L SylvesterRobert C Sergott
Jun 28, 2019·Current Opinion in Ophthalmology·Marybeth K FarazdaghiRobert A Avery
Nov 22, 2014·The Cancer Journal·Bree R Eaton, Torunn Yock
Oct 27, 2018·Ophthalmic Plastic and Reconstructive Surgery·Gishan S RatnayakeJeremy D Ruben
May 11, 2018·Journal of Korean Neurosurgical Society·Eun Suk ParkYoung-Shin Ra
Jan 13, 2012·Journal of Neuro-oncology·Mark V MishraYaacov Richard Lawrence
Sep 29, 2006·Expert Review of Anticancer Therapy·Kiran DevisettySteven J Chmura
Jul 14, 2007·Pediatric Neurosurgery·Seong Rok HanChoong Jin Whang
Mar 4, 2020·Neuroendocrinology·Luigi AlbanoGiuseppe Minniti

❮ Previous
Next ❯

Related Concepts

Related Feeds

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Related Papers

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Stephanie E CombsDaniela Schulz-Ertner
International Journal of Radiation Oncology, Biology, Physics
Daniela Schulz-ErtnerJürgen Debus
Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
Daniela Schulz-ErtnerMichael Wannenmacher
Pediatric Blood & Cancer
Christopher D Jahraus, N J Tarbell
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Saba SharifD Gareth R Evans
© 2022 Meta ULC. All rights reserved