PMID: 8949754Jan 1, 1996Paper

Fractionation and therapeutic ratio with neutron therapy

Bulletin du cancer. Radiothérapie : journal de la Société française du cancer : organe de la société française de radiothérapie oncologique
A Courdi

Abstract

Dose-response relationships of most tumours and normal tissues after neutron irradiation are characterized by relatively high alpha/beta ratios. Late reacting tissues are not as protected by low doses per fraction as they are after low linear energy transfer (LET) irradiation. Using the linear-quadratic (LQ) model with the time factor (when needed), we have calculated the therapeutic ratio (TR) as the ratio of the effect on a tumour (or an acutely responding tissue) over that on late reacting tissue. Hypothetical cases are given as well as a case derived from LQ parameters obtained experimentally in animals. It is shown that X-ray fractionation schemes that lead to a high TR will lead to a low neutron TR. For epithelial tumours, a neutron gain factor, GF (ratio of TR) is possible if neutron fractionation is compared to hypofractionated X-irradiation. Neutron treatment over conventional overall times of rapidly proliferating tumours carries a low TR and offers no GF. Neutron therapy for tumours with low alpha/beta ratios offer a potential advantage compared to tumours with high alpha/beta ratios.

References

Nov 1, 1990·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·H D ThamesW Van den Bogaert
Dec 1, 1982·International Journal of Radiation Oncology, Biology, Physics·H R WithersL J Peters
Dec 1, 1982·International Journal of Radiation Oncology, Biology, Physics·S Hornsey

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