Fracture, bone mineral density, and the effects of calcitonin receptor gene in postmenopausal Koreans.

Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
H-J LeeJ-Y Lee

Abstract

In a candidate gene association study, we found that the variations of calcitonin receptor (CALCR) gene were related to the risk of vertebral fracture and increased bone mineral density (BMD). Calcitonins through calcitonin receptors inhibit osteoclast-mediated bone resorption and modulate calcium ion excretion by the kidney and also prevent vertebral bone loss in early menopause. To identify genetically susceptible factors of osteoporosis, we discovered the variations in CALCR gene, genotyped in Korean postmenopausal women (n = 729), and examined the potential involvement of seven single-nucleotide polymorphism (SNPs) and their haplotypes in linkage disequilibrium block (BL_hts). The SNPs, +43147G > C (intron 7), +60644C > T (exon13, 3' untranslated region), and their haplotypes, BL2_ht1 and BL2_ht2, showed a significant association with risk of vertebral fracture (p = 0.048-0.004) and BL2_ht1 showed a highly significant protective effect. Moreover, the polymorphism +60644C > T showed a highly significant association with BMD at both lumbar spine and femoral neck. The subjects carrying CC and CT genotypes with the SNP, +60644C > T, had higher BMD values at the lumbar spine (p = 0.01-0.001) and femoral neck (p = 0.025-0.009). T...Continue Reading

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Citations

Jan 26, 2006·BMC Neuroscience·Thomas A Cleland, Praveen Sethupathy
Apr 11, 2013·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Seung Hun LeeChangwon Kang
Dec 3, 2014·Experimental and Therapeutic Medicine·Qi XiongPeifu Tang
May 14, 2016·Journal of Periodontal Research·S B FarhatP C Trevilatto
Sep 3, 2013·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Keiji Nagano
Oct 19, 2019·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Jiaxuan QinPeide Bai
Oct 28, 2019·Bone Research·Jian LuoJianru Xiao
Aug 29, 2019·Genes·Katharina C Wollenberg ValeroSebastian Steinfartz
Jul 10, 2021·Oxidative Medicine and Cellular Longevity·Lang YangJunxiang Peng

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