Fracture-related infections in traumatology : Current standards and new developments in diagnostics and treatment

Der Orthopäde
Hinnerk BaeckerY Hanusrichter

Abstract

The high demands that fracture-related infections put on patients, physicians and the healthcare system have led to the establishment of a international group of experts called the Fracture-Related Infection (FRI) Consensus Group, whose aim is to develop evidence-based treatment recommendations. Fracture-related infections are classified according to the time of occurrence, extent and treatment options. The diagnostic algorithm distinguishes between confirmatory and suggestive diagnostic criteria. If there are indications of an infection, tissue biopsy with microbiological and histological workup is recommended to confirm the diagnosis. The primary objective of FRI treatment is to achieve fracture consolidation, while avoiding osteomyelitis. Therapeutic options are removal of the implant, eradication of the infection with implant retention or suppression of FRI. A multidisciplinary team is recommended to develop a patient-specific, optimized surgical and antimicrobial therapy.

References

Sep 11, 2003·Clinical Orthopaedics and Related Research·George CiernyJohan J Penninck
Dec 19, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Timothy H DellitUNKNOWN Society for Healthcare Epidemiology of America
Aug 19, 2007·The New England Journal of Medicine·Andrej TrampuzRobin Patel
Jul 8, 2016·HSS Journal : the Musculoskeletal Journal of Hospital for Special Surgery·Joseph J RuzbarskyEmily Dodwell
Nov 4, 2017·Tissue Engineering. Part a·Jan GessmannManfred Köller
Dec 2, 2017·Diagnostic Microbiology and Infectious Disease·Christian MorgensternNora Renz
Jun 30, 2018·The Bone & Joint Journal·M MorgensternM A McNally
Oct 22, 2018·Archives of Orthopaedic and Trauma Surgery·H BezstarostiM H J Verhofstad
Jan 27, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Alberto SignorePaul C Jutte
Jan 31, 2019·The New England Journal of Medicine·Ho-Kwong LiUNKNOWN OVIVA Trial Collaborators
Aug 20, 2019·EFORT Open Reviews·Petra IzakovicovaAndrej Trampuz
Aug 30, 2019·Journal of Orthopaedic Trauma·Willem-Jan MetsemakersUNKNOWN Fracture-Related Infection (FRI) consensus group
Oct 1, 2019·Journal of Orthopaedic Trauma·Melissa DepypereUNKNOWN Fracture-Related Infection (FRI) Consensus Group
Oct 30, 2019·Archives of Orthopaedic and Trauma Surgery·Willem-Jan MetsemakersUNKNOWN Fracture-Related Infection (FRI) group
Dec 20, 2019·Journal of Orthopaedic Trauma·Geertje A M GovaertUNKNOWN Fracture-Related Infection (FRI) Consensus Group

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